PMID: 9531376Apr 8, 1998Paper

How successful is high-dose (> or = 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma?

International Journal of Radiation Oncology, Biology, Physics
P M TeoC O Mok

Abstract

To evaluate the efficacy of high-dose (> or = 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma (NPC) after modern primary radical radiotherapy that delivered radical dose-to-target volumes defined by CT scan. Nine hundred and three patients with nondisseminated NPC whose primary radical radiotherapy was administered between 1984 and 1989 inclusive were studied. One hundred and seventy-six had local failures comprising 9 persistences and 167 recurrences. In 10 patients the local failures were preceded or accompanied by (within 2 months) distant metastases, and these were given supportive treatment or palliative radiotherapy in low dose (< 60 Gy) if symptomatic. Most of the rest (123 of 166) were treated with either reirradiation to high dose (> or = 60 Gy) using mainly external photon beams (n = 103) or nasopharyngectomy with/without radical neck dissection with/without postoperative radiotherapy (n = 20). The remainder (n = 43) received only palliative treatments because of poor general condition and/or patients' refusal of radical treatments. The primary radiotherapy was planned on the basis of target volumes defined by CT scan and given to a standard nasopharyngeal dose ...Continue Reading

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