How sunlight causes melanoma.

Current Oncology Reports
Lilit Garibyan, David E Fisher

Abstract

The incidence of melanoma has continued to rise dramatically over the past few decades, especially in young females. Due to the deadly nature of this disease, melanoma has become an important public health problem. It is generally accepted that ultraviolet light radiation (UVR) from sunlight is a major risk factor for melanoma skin cancer development. However, the mechanistic details of how sunlight via UVR causes melanoma are still being elucidated. Currently, it is thought that carcinogenic, inflammatory, and immunosuppressive properties of UVR all contribute to initiation, progression, and metastasis of primary melanoma. We review current findings on how sunlight-generated UVR generates DNA damage, inflammation, and immune suppression, thus leading to melanoma.

References

Aug 1, 1988·The Journal of Investigative Dermatology·M A SteneA J Cochran
Oct 1, 1987·The British Journal of Dermatology·J S English, A J Swerdlow
Dec 22, 1994·Nature·A ZieglerD E Brash
Jan 1, 1996·The British Journal of Dermatology·P Clement-LacroixL Dubertret
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A S JonasonD E Brash
Aug 17, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I Penn
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·B K Armstrong, A Kricker
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·J L RavanatJ Cadet
Feb 7, 2002·Journal of the National Cancer Institute·Margaret R KaragasMartin A Weinstock
Apr 23, 2002·The British Journal of Dermatology·Thomas L Diepgen, V Mahler
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Nov 26, 2002·Nature Genetics·Pamela M PollockPaul S Meltzer
Nov 27, 2002·Journal of the American Academy of Dermatology·Michael R Albert, Kristen G Ostheimer
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 25, 2003·The New England Journal of Medicine·Sylvie EuvrardAlain Claudy
Jul 24, 2003·Annals of Epidemiology·Cedric F GarlandEdward D Gorham
Dec 23, 2003·Cancer Biology & Therapy·Erinn B RankinAndrei Thomas-Tikhonenko
Jan 8, 2004·Critical Reviews in Clinical Laboratory Sciences·Diana M StafforiniStephen M Prescott
Mar 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nita S AgarAlexandra M Jones
Apr 3, 2004·Journal of Medical Genetics·R H EdwardsB L Weber
May 14, 2004·The Journal of Investigative Dermatology·Nancy E ThomasKathleen Conway
Jun 11, 2004·Annual Review of Biochemistry·Aziz SancarStuart Linn
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Feb 4, 2005·Journal of Biomedicine & Biotechnology·Mandy Williams, Allal Ouhtit
Mar 8, 2005·Mutation Research·Jean CadetThierry Douki
Jun 10, 2005·Nature·Alberto Mantovani
Sep 13, 2005·Surgery·Martin McCarterCara Wilson
Nov 18, 2005·The New England Journal of Medicine·John A CurtinBoris C Bastian
Dec 14, 2005·Carcinogenesis·Ahmad Besaratinia, Gerd P Pfeifer
Dec 29, 2005·American Journal of Public Health·Cedric F GarlandMichael F Holick
Aug 11, 2006·Trends in Molecular Medicine·Wynand P Roos, Bernd Kaina
Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stéphane MouretThierry Douki
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·UNKNOWN International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer
Apr 20, 2007·Molecular Carcinogenesis·Stephen E Ullrich
May 18, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nancy E ThomasKathleen Conway
Aug 28, 2007·Cancer Metastasis Reviews·Vladislava Melnikova, Menashe Bar-Eli
Jan 5, 2008·International Journal of Dermatology·William TingHobart W Walling
Jan 9, 2008·Photochemistry and Photobiology·Agatha SchwarzThomas Schwarz
Feb 6, 2008·Photochemistry and Photobiology·Nityanand Maddodi, Vijayasaradhi Setaluri
Apr 19, 2008·Human Mutation·Ahmad Besaratinia, Gerd P Pfeifer
May 15, 2008·Journal of Medical Imaging and Radiation Oncology·M J Veness
Jul 11, 2008·The Journal of Investigative Dermatology·Mark P PurdueMargaret A Tucker
Sep 30, 2008·Pigment Cell & Melanoma Research·T Thanh-Nga TranDavid E Fisher
Feb 24, 2009·Occupational Medicine·Charlotte Young

❮ Previous
Next ❯

Citations

Jan 21, 2011·Nature·M Raza ZaidiGlenn Merlino
May 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ahmad BesaratiniaGerd P Pfeifer
Jul 13, 2012·Environmental Health : a Global Access Science Source·Katarina VolkovovaMaria Dusinska
May 8, 2014·BioMed Research International·Garry Egger, John Dixon
Dec 3, 2014·Archives of Gerontology and Geriatrics·Angela Yee Man LeungIris Chi
Jul 19, 2014·Cell Research·Yeon Sook Choi, David E Fisher
Jun 5, 2014·Journal of Molecular Cell Biology·Ahmad Besaratinia, Stella Tommasi
Sep 4, 2015·CNS Neuroscience & Therapeutics·Douglas M Lopes, Stephen B McMahon
Oct 6, 2012·Mayo Clinic Proceedings·Agnieszka W Kubica, Jerry D Brewer
Nov 22, 2011·Clinics in Plastic Surgery·Florian GroeberKatja Schenke-Layland
Nov 30, 2011·Seminars in Cutaneous Medicine and Surgery·Holly E Kanavy, Meg R Gerstenblith
Jan 19, 2011·Advanced Drug Delivery Reviews·Florian GroeberKatja Schenke-Layland
Apr 25, 2014·The Journal of Investigative Dermatology·Hongxiang ChenDavid E Fisher
Jun 14, 2013·The Journal of Investigative Dermatology·Tao Wang, Meenhard Herlyn
Nov 29, 2014·Pigment Cell & Melanoma Research·Lauren G AoudeNicholas K Hayward
Oct 13, 2011·International Journal of Cancer. Journal International Du Cancer·Meg R GerstenblithD Michal Freedman
Jun 29, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·A JuzenieneJ Moan
Mar 7, 2014·The Australasian Journal of Dermatology·Niamh-Anna O'Sullivan, Clare P Tait
Oct 11, 2013·Pigment Cell & Melanoma Research·Russell R BraeuerMenashe Bar-Eli
Jun 25, 2015·Archives of Dermatological Research·Sudipta SinnyaH Peter Soyer
Nov 22, 2014·Science·Jennifer A Lo, David E Fisher
Jul 24, 2012·Cell·Eran HodisLynda Chin
Jan 20, 2015·Cancer Letters·Leah Ray StricklandFarrukh Afaq
Oct 25, 2016·The Journal of Investigative Dermatology·Kanad Ghosh, Brian C Capell
Sep 21, 2016·Photochemistry and Photobiology·Stuart G Jarrett, John A D'Orazio
Jan 11, 2013·International Journal of Molecular Sciences·Timothy Budden, Nikola A Bowden
Jul 19, 2018·Pigment Cell & Melanoma Research·Nhu T Nguyen, David E Fisher
Apr 2, 2015·Experimental Dermatology·Georgios NikolakisChristos C Zouboulis
Sep 26, 2019·Frontiers in Medicine·Takanori HidakaSetsuya Aiba
Feb 18, 2020·Drug and Chemical Toxicology·Luiza Martins LongarettiVanessa Moraes de Andrade
Jan 5, 2018·Chemical Communications : Chem Comm·M U Anu PrathapSundaram Gunasekaran
Dec 14, 2016·Annual Review of Pathology·William M Lin, David E Fisher
Sep 15, 2018·Frontiers in Medicine·Mariachiara ArisiPiergiacomo Calzavara-Pinton
Jul 28, 2020·Frontiers in Oncology·Xiaoying SunXin Li
Dec 20, 2020·International Journal of Molecular Sciences·Monica HesslerKamran Avanaki
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta CassanoSonia Trombino
Jul 3, 2021·Cancers·Rossella PuglisiGianfranco Mattia
Jul 19, 2021·Journal of Exposure Science & Environmental Epidemiology·Tristan R FraserClaire E Lenehan
May 23, 2021·Integrative and Comparative Biology·Silvia Benito-MartínezCédric Delevoye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.