How the innate immune system trains immunity: lessons from studying atopic dermatitis and cutaneous bacteria

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Y SkabytskaT Biedermann

Abstract

The skin is the largest organ at the interface between environment and host. It plays a major protective role against pathogens as physical barrier, as site of first recognition, and as orchestrator of consecutive immune responses. In this process, immunological crosstalk between skin-resident and immune cells is required, and fixed innate immune responses were previously believed to orchestrate adaptive immunity of B and T lymphocytes. Today, we understand that diverse qualities of immune responses to different microbes need to be regulated by also varying responses at the level of first microbe recognition through receptors of the innate immune system. Only fine-tuning of the innate immune system allows for the orchestration of immune responses to the microbiota in the absence of inflammation as well as to pathogens in the context of protective responses including inflammation. Understanding how innate immunity precisely adapts is also important for diseases such as atopic dermatitis (AD) with chronic inflammation. In this review, we present data on how the innate immune system actually fine-tunes its responses with special focus on the immunological consequences of cutaneous innate immune sensing through TLR2. These new insi...Continue Reading

References

Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Aug 2, 2003·Journal of the American Academy of Dermatology·Andreas WollenbergBernhard Przybilla
Dec 8, 2004·European Journal of Immunology·Ute Buwitt-BeckmannArtur J Ulmer
Feb 4, 2005·Nature·Kasper HoebeBruce Beutler
Oct 26, 2007·The Journal of Investigative Dermatology·Rieko KurahashiKazumoto Katagiri
Jan 22, 2008·The Journal of Allergy and Clinical Immunology·Joohee LeeLeonard Bielory
Dec 3, 2010·PloS One·Martina BarrenscheeStefan Uhlig
Oct 19, 2011·The Journal of Clinical Investigation·Ana Paula MoreiraCory M Hogaboam
Jul 28, 2012·Science·Shruti NaikYasmine Belkaid
Mar 4, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sebastian Willenborg, Sabine A Eming
Apr 5, 2014·The Journal of Allergy and Clinical Immunology·Susanne KaeslerTilo Biedermann
Jun 9, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marc Schmidt, Matthias Goebeler

❮ Previous
Next ❯

Citations

Jan 29, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Timo Buhl
Jul 26, 2016·Frontiers in Immunology·Rachel T EsraClive M Gray
Aug 19, 2021·Allergy·Claudia HülpüschMatthias Reiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.