How the thyroid controls metabolism in the rat: different roles for triiodothyronine and diiodothyronines

The Journal of Physiology
M MorenoFernando Goglia

Abstract

1. Although the first evidence of a relationship between the thyroid and metabolism was reported in 1895, the mechanism by which thyroid hormones influence resting metabolic rate in whole animals is still poorly understood. This paper reports an attempt to test whether diiodothyronines (T2s) and triiodothyronine (T3) have different roles in the control of resting metabolism (RM). 2. Changes in resting metabolic rate were measured in hypothyroid rats treated acutely (25 micrograms (100 g body weight)-1) either with one of the T2s or with T3. Injection of T3 induced an increase of about 35% in RM that started 25-30 h after the injection and lasted until 5-6 days after the injection, the maximal value being observed at 50-75 h. The injection of T2s evoked a temporally different pattern of response. The increases in RM started 6-12 h after the injection, had almost disappeared after 48 h, and the maximal stimulation was observed at 28-30 h. 3. When actinomycin D (an inhibitor of protein synthesis) and T3 were given together, the stimulation of RM was almost completely abolished. The simultaneous injection of actinomycin D and either of the T2s, on the other hand, did not cause any attenuation of the stimulation seen with the T2s al...Continue Reading

References

May 1, 1977·The Journal of Endocrinology·T J VisserG Hennemann
Aug 1, 1992·Molecular and Cellular Endocrinology·A LanniF Goglia
Dec 1, 1992·Acta Endocrinologica·I O'Reilly, M P Murphy
Apr 1, 1991·The Journal of Endocrinology·S FrancavillaM D'Armiento
Jan 1, 1991·The Journal of Clinical Investigation·J H OppenheimerM P Thompson
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·H BarréJ L Rouanet
Aug 1, 1987·Endocrine Reviews·J H OppenheimerH C Freake
Jul 1, 1988·The Journal of Clinical Endocrinology and Metabolism·T J VisserE P Krenning
Jul 1, 1980·The Journal of Clinical Endocrinology and Metabolism·K J Acheson, A G Burger
Mar 1, 1983·Endocrinology·J L LeonardP R Larsen
Oct 30, 1981·Science·J L LeonardP R Larsen
Dec 1, 1994·Journal of Molecular Endocrinology·F GogliaR Thoma
Aug 16, 1993·Biochimica Et Biophysica Acta·S Soboll
Jan 1, 1993·The Journal of Endocrinology·A LanniF Goglia
Aug 1, 1996·The Journal of Physiology·A LanniF Goglia
Mar 1, 1963·The Biochemical Journal·J R TATAR HEDMAN

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Citations

Jul 9, 2011·Journal of Bioenergetics and Biomembranes·Alessandro CavalloGabriele Vincenzo Gnoni
Apr 6, 2004·Molecular and Cellular Endocrinology·J H Duncan BassettGraham R Williams
Dec 31, 2003·General and Comparative Endocrinology·Carlota García-GAurea Orozco
Nov 15, 2000·Biochemical Pharmacology·X LiR J Anderson
Aug 2, 2003·Molecular and Cellular Endocrinology·Paola VendittiSergio Di Meo
Oct 18, 2000·Free Radical Biology & Medicine·B KadenbachE Bender
Jun 5, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sandra G RoblesEdmundo Chávez
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·Paul J Davis, Faith B Davis
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Sing-Yung WuInder J Chopra
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Maria MorenoFernando Goglia
Dec 5, 2000·Pediatric Research·S Y WuV A Galton
Dec 6, 2005·Pediatric Research·Sing-Yung WuDelbert A Fisher
Nov 24, 2011·The Journal of Endocrinology·Elena GrasselliLaura Vergani
Sep 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mark D ErionDavid L Linemeyer
Jan 31, 2002·Journal of Endocrinological Investigation·A LanniF Goglia
Nov 8, 2001·Free Radical Research·R GredillaM López-Torres
Jul 21, 2015·International Journal of Molecular Sciences·Janina A VaitkusFrancesco S Celi
Dec 17, 2015·Nature Reviews. Endocrinology·Paul J DavisJack L Leonard
Aug 4, 2010·General and Comparative Endocrinology·Sutapa ChattopadhyayLuna Samanta
Jul 20, 2005·Acta Physiologica Scandinavica·E SilvestriF Goglia
Feb 15, 2005·Placenta·M D KilbyJ A Franklyn
Nov 22, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Céline Aguer, Mary-Ellen Harper
May 16, 2006·Biochimica Et Biophysica Acta·Anna M GiudettiGabriele V Gnoni
Jan 30, 2015·Frontiers in Physiology·Fernando Goglia
Oct 25, 2014·Thyroid : Official Journal of the American Thyroid Association·Maik PietznerHenri Wallaschofski
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Nov 18, 2016·Journal of Bioenergetics and Biomembranes·Alessandro CavalloAntonio Gnoni
Mar 17, 2017·Langenbeck's Archives of Surgery·Gregorio ScerrinoGaspare Gulotta
Jul 3, 2018·Redox Report : Communications in Free Radical Research·Georgeta BochevaBoycho Landzhov
Nov 5, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J NiezgodaD Wrońska-Fortuna
Feb 28, 2002·Endocrinology·Monique H A KesterTheo J Visser

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