How to assess the best immunohistochemical panel in the diagnosis of malignant pleural mesothelioma in a pathology lab

Journal of Immunoassay & Immunochemistry
Mona MlikaFaouzi El Mezni

Abstract

malignant pleural mesothelioma (MPM) is a rare tumor with a challenging diagnosis. Even if, clinical data are mandatory to suspect the diagnosis, the positive diagnosis is based on microscopic features. Morphologic features are still the port of call of the diagnosis but their non specific character and the multiplicity of differential diagnoses made the immunohistochemical markers mandatory for the diagnosis. Many antibodies with a positive diagnostic value including claretinin, mesothelin, WT1 and antibodies with a negative diagnostic value including TTF1, EMA, CD15 are recommended by the scientific societies. This is due to the diagnostic limits of every antibody which necessitate the association of multiple antibodies. In the diagnostic demarch, pathologists deal with different antibodies and clones. Even if many recommendations are available, every pathology lab has to experiment its own antibodies in order to optimize the routine diagnostic demarch especially in low-income country. Our aim was to assess the diagnostic value of different antibodies available in our lab and to recommend a decisional flowchart. we conducted a retrospective study about 30 MPM diagnosed over a 20-year-period. The different techniques were real...Continue Reading

References

Jan 19, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonja KlebeVictor L Roggli
Apr 14, 2012·Advances in Anatomic Pathology·Nelson G Ordóñez
Jan 27, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Francoise Galateau-SalleUNKNOWN World Health Organization Committee for Tumors of the Pleura
Aug 4, 2016·Pathology, Research and Practice·Valeria AscoliFrancesco Forastiere
Mar 7, 2018·Journal of Thoracic Disease·Greta AlìGabriella Fontanini

❮ Previous
Next ❯

Citations

Sep 25, 2021·Asian Cardiovascular & Thoracic Annals·Mona MlikaFaouzi Mezni

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
X-ray

Software Mentioned

Leica

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.