How to avoid the impact of environmental mycobacteria towards the efficacy of BCG vaccination against tuberculosis?

International Journal of Mycobacteriology
Om Parkash

Abstract

Bacillus Calmette-Guérin (BCG) remains the only widely used vaccine against tuberculosis (TB). Consistent efficacy has been proved in infants but not in adults from developing countries. Epidemiological and experimental studies have pointed out that, prior exposure to prevailing environmental mycobacteria could be responsible for the poor efficacy of BCG as an anti-TB vaccine in adults living in developing countries. Sensitization by environmental mycobacteria may down-modulate the immunologic behavior of BCG on the one hand and may mask its efficacy on the other hand. Some of the important deciding factors for poor efficacy of BCG, due to exposure of the subjects to prevailing environmental mycobacteria, are thought to be (i) Life stage: neonatus versus adolescence; (ii) shared antigens between prevailing environmental mycobacteria and BCG; and (iii) generation of cross-reactive T-regulatory cells against environmental mycobacteria and BCG. In this communication, some novel strategies have been discussed for countering the down modulating impact of environmental mycobacteria towards performance of BCG as an anti-TB vaccine.

References

Jan 17, 2004·Clinical Microbiology Reviews·Todd P PrimmJoseph O Falkinham
Jul 9, 2004·Journal of Leukocyte Biology·Angelo MartinoSilvia Vendetti
Nov 2, 2004·Nature Reviews. Immunology·Kingston H G Mills
Jul 5, 2005·Nature Reviews. Neuroscience·Fabien MarchandStephen B McMahon
Jul 14, 2005·Nature Reviews. Microbiology·Peter Andersen, T Mark Doherty
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Valerie Guyot-RevolAjit Lalvani
Mar 18, 2006·Clinical and Experimental Immunology·R Ribeiro-RodriguesC S Hirsch
Jan 20, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xinchun ChenEmmanuel Katsanis
Jun 2, 2007·American Journal of Respiratory and Critical Care Medicine·Jean-Michel HougardyFrancoise Mascart
Feb 28, 2009·American Journal of Respiratory and Critical Care Medicine·Prabhat K SharmaDipendra K Mitra
Mar 17, 2009·Clinical and Molecular Allergy : CMA·Subhadra NandakumarUday Kumaraguru
Feb 27, 2010·Clinical and Experimental Immunology·C F InmanC Stokes
Dec 3, 2010·Journal of Leukocyte Biology·Michelle M ColemanKingston H G Mills
May 17, 2012·PLoS Pathogens·Tom H M Ottenhoff, Stefan H E Kaufmann
Mar 22, 2013·Genome Biology·Scott T Kelley, Jack A Gilbert
Mar 23, 2013·BJU International·Nilay M GandhiDonald L Lamm
Apr 5, 2013·Bulletin of the World Health Organization·Haileyesus GetahunMario Raviglione
May 17, 2013·Seminars in Hematology·Tetsuya Nishimoto, Masataka Kuwana
Aug 3, 2013·Folia medica·Evelina K VetskovaMaria H Nikolova

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Citations

Sep 22, 2016·International Journal of Mycobacteriology·Seyed MohammadReza HashemianAli Akbar Velayati
May 8, 2015·Immunologic Research·Om ParkashM Madhan Kumar
May 24, 2017·Expert Review of Vaccines·Magdalena Kowalewicz-Kulbat, Camille Locht
Aug 4, 2021·Survey of Ophthalmology·Manish JainJyotirmay Biswas
May 19, 2020·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Abu Salim Mustafa

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