How to bake a brain: yeast as a model neuron

Current Genetics
Isabella Sarto-Jackson, Lubomir Tomaska

Abstract

More than 30 years ago Dan Koshland published an inspirational essay presenting the bacterium as a model neuron (Koshland, Trends Neurosci 6:133-137, 1983). In the article he argued that there are several similarities between neurons and bacterial cells in "how signals are processed within a cell or how this processing machinery can be modified to produce plasticity". He then explored the bacterial chemosensory system to emphasize its attributes that are analogous to information processing in neurons. In this review, we wish to expand Koshland's original idea by adding the yeast cell to the list of useful models of a neuron. The fact that yeasts and neurons are specialized versions of the eukaryotic cell sharing all principal components sets the stage for a grand evolutionary tinkering where these components are employed in qualitatively different tasks, but following analogous molecular logic. By way of example, we argue that evolutionarily conserved key components involved in polarization processes (from budding or mating in Saccharomyces cervisiae to neurite outgrowth or spinogenesis in neurons) are shared between yeast and neurons. This orthologous conservation of modules makes S. cervisiae an excellent model organism to in...Continue Reading

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Citations

Oct 14, 2017·Current Genetics·Tatyana A RyzhovaAlexey P Galkin
Sep 22, 2017·Current Genetics·Andrew G MatveenkoGalina A Zhouravleva
Apr 23, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Oné R Pagán
Mar 7, 2021·International Journal of Molecular Sciences·Peter Polčic, Zdenko Machala
Aug 14, 2020·Cell Reports·Peter TsvetkovSusan Lindquist

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