How to breakthrough mitochondrial DNA methylation-associated networks.

Cell Biology and Toxicology
William WangXiangdong Wang

Abstract

Mitochondrial DNA (mtDNA) plays an important role in regulating mitochondrial homeostasis, transcription, cell metabolism, and drug sensitivity. Patterns and regulations of mtDNA methylation vary among cell types, species, functions, and diseases. High-resolution mtDNA methylation maps of human and animal mitochondrial genomes addressed that the light (L)-strand non-CpG methylation of mtDNA varied among species, developing stages, and ages. Of DNA methyltransferases, DNMT3A was a critical enzyme in the dynamic regulation of mtDNA regional methylation patterns and strand bias. Altered mtDNA methylations may regulate dynamic occurrences of pathogenic mtDNA mutations. The number and sites of control regions, involved enzymes, and regulators during mtDNA methylation may vary among cell types and diseases. Specific regulatory and functional networks associated with mtDNA methylation mainly include mtDNA, regulatory factors, methyltransferases, nucleotides, mt-rRNAs, and other epigenetic modifications. Those carry out precise functions and regulations of mtDNA methylation-associated network, interactions with genome DNA and other signal pathways, and decisive roles in patient phenomes. A breakthrough in mtDNA methylation-associated n...Continue Reading

References

Mar 22, 2016·Scientific Reports·Baojing LiuCong Bin
Nov 28, 2017·Advances in Experimental Medicine and Biology·Hongzhi SunXiangdong Wang
Nov 28, 2017·Advances in Experimental Medicine and Biology·Danyan GaoXiangdong Wang
Apr 25, 2018·Cell Biology and Toxicology·Xiangdong Wang
Feb 27, 2019·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Vishantie Dostal, Mair E A Churchill
May 24, 2019·Cell Biology and Toxicology·Tingting FangXiawei Wei
Sep 21, 2019·Genome Research·Xiaoyang DouJing-Dong J Han
Mar 19, 2020·Molecular Cell·Ziyang HaoChuan He
Jun 9, 2020·Clinical and Translational Medicine·Furong YanYiming Zeng

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Citations

Aug 1, 2020·Cell Biology and Toxicology·Willian Wang, Xiangdong Wang
Jun 18, 2020·Cell Biology and Toxicology·William WangXiangdong Wang
Aug 31, 2021·Clinical and Translational Medicine·Liyang LiXiangdong Wang
Jan 28, 2022·Clinical and Translational Medicine·Xiaoxia LiuXiangdong Wang

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