How to build the fastest receptor on earth

Biological Chemistry
Jelena Baranovic, Andrew J R Plested

Abstract

In 2014, a slew of structures of glutamate receptors were published, based on crystallography and electron microscopy. Here we review these insights, integrate them with existing knowledge about receptor function and try to understand how the structures relate to the key property of the AMPA receptor--its speed.

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Citations

Jun 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Linda G ZachariassenAnders S Kristensen
Aug 14, 2020·The Journal of Physiology·David Stroebel, Pierre Paoletti
Jun 1, 2021·Neuropharmacology·David StroebelPierre Paoletti
Jul 17, 2021·Neuropharmacology·Jelena Baranovic

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Methods Mentioned

BETA
NMR
atomic-force microscopy
glycosylation
protein folding
FRET
atomic force microscopy

Software Mentioned

NOW
PyMOL

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