How to Conduct and Interpret Systematic Reviews and Meta-Analyses

Clinical and Translational Gastroenterology
Siddharth Singh

Abstract

Systematic reviews with or without meta-analyses serve a key purpose in critically and objectively synthesizing all available evidence regarding a focused clinical question and can inform clinical practice and clinical guidelines. Performing a rigorous systematic review is multi-step process, which includes (a) identifying a well-defined focused clinically relevant question, (b) developing a detailed review protocol with strict inclusion and exclusion criteria, (c) systematic literature search of multiple databases and unpublished data, in consultation with a medical librarian, (d) meticulous study identification and (e) systematic data abstraction, by at least two sets of investigators independently, (f) risk of bias assessment, and (g) thoughtful quantitative synthesis through meta-analysis where relevant. Besides informing guidelines, credible systematic reviews and quality of evidence assessment can help identify key knowledge gaps for future studies.

References

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Citations

Jan 17, 2019·The American Journal of Sports Medicine·Joash R SuryavanshiPeter D Fabricant
Sep 5, 2017·Journal of Prosthodontic Research·Sreenivas Koka, Avni Gupta
Jul 30, 2020·The Cochrane Database of Systematic Reviews·Solange DuraoAnel Schoonees
Aug 8, 2020·The Cochrane Database of Systematic Reviews·Solange DuraoAnel Schoonees
Aug 16, 2018·Environmental Research Letters : ERL [Web Site]·Keely MaxwellJenifer Buckley
Mar 7, 2020·Environmental Science & Policy·Keely MaxwellEmily Eisenhauer
Dec 7, 2021·Current Medical Research and Opinion·Niraj Nirmal Pandey, Sanjiv Sharma

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Software Mentioned

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