How to Construct, Conduct and Analyze an Exercise Training Study?

Frontiers in Physiology
Anne HeckstedenLars Donath

Abstract

Randomized controlled trials (RCTs) can be regarded as gold standard in investigating dose-response and causal relationships in exercise science. Recommendations for exercise training routines and efficacy analyses of certain training regimen require valid data derived from robust RCTs. Moreover, meta-analyses rely on RCTs and both RCTs and meta-analyses are considered the highest level of scientific evidence. Beyond general study design a variety of methodological aspects and notable pitfalls has to be considered. Therefore, exercise training studies should be carefully constructed focusing on the consistency of the whole design "package" from an explicit hypothesis or research question over study design and methodology to data analysis and interpretation. The present scoping review covers all main aspects of planning, conducting, and analyzing exercise based RCTs. We aim to focus on relevant aspects regarding study design, statistical power, training planning and documentation as well as traditional and recent statistical approaches. We intend to provide a comprehensive hands-on paper for conceptualizing future exercise training studies and hope to stimulate and encourage researchers to conduct sound and valid RCTs in the fie...Continue Reading

References

Jan 1, 1991·Journal of Biopharmaceutical Statistics·L D Fisher
Jul 25, 2000·Sports Medicine·W G Hopkins
Feb 13, 2001·BMJ : British Medical Journal·J A Sterne, G Davey Smith
Jul 11, 2001·Complementary Therapies in Medicine·A White, E Ernst
Mar 7, 2002·Lancet·Kenneth F Schulz, David A Grimes
Dec 31, 2002·Controlled Clinical Trials·Neil W ScottMarion K Campbell
Oct 23, 2004·BMJ : British Medical Journal·Stephen Senn
Apr 2, 2005·Zeitschrift für Kardiologie·T MeyerW Kindermann
Apr 9, 2005·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Jul 29, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Tim MeyerWilfried Kindermann
Jan 9, 2007·European Journal of Public Health·Noora Maria SjöstenSirkka-Liisa Kivelä
Apr 7, 2007·Medicine and Science in Sports and Exercise·Jan HelgerudJan Hoff
Sep 1, 2007·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Ruth LindquistCynthia R Gross
Feb 19, 2008·Sports Medicine·Chris R Abbiss, Paul B Laursen
Mar 20, 2008·Sports Medicine·Kevin Currell, Asker E Jeukendrup
Apr 22, 2008·The Cochrane Database of Systematic Reviews·R B HaynesX Yao
Jul 29, 2008·The American Journal of Sports Medicine·Julie GilchristJiri Dvorak
Feb 10, 2009·British Journal of Sports Medicine·C F Finch, A Donaldson
Mar 26, 2009·Sports Medicine·Christopher J Beedie, Abigail J Foad
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·John A Hawley
May 21, 2009·Sports Medicine·Oliver FaudeTim Meyer
Jun 12, 2009·Medicine and Science in Sports and Exercise·Wojtek J Chodzko-ZajkoJames S Skinner
Mar 2, 2010·Journal of Clinical Epidemiology·Emmy M HertoghEvelyn M Monninkhof
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
Mar 25, 2010·BMJ : British Medical Journal·Sally HopewellDouglas G Altman
Mar 25, 2010·BMJ : British Medical Journal·David MoherDouglas G Altman
Jun 22, 2010·Scandinavian Journal of Medicine & Science in Sports·F Scharhag-RosenbergerT Meyer
Sep 24, 2010·International Journal of Sports Physiology and Performance·Stephen Seiler
Sep 24, 2010·International Journal of Sports Physiology and Performance·Michael Ian Lambert, Jill Borresen
Jun 3, 2011·New South Wales Public Health Bulletin·Catherine SherringtonStephen R Lord
Jun 2, 2012·Journal of Biopharmaceutical Statistics·William F RosenbergerFeifang Hu
Aug 21, 2012·Statistics in Medicine·Douglas G AltmanKenneth F Schulz
Sep 7, 2012·BMJ : British Medical Journal·Marion K CampbellUNKNOWN CONSORT Group
Sep 29, 2012·Journal of Clinical Epidemiology·Gerard J P van Breukelen, Math J J M Candel
Dec 21, 2012·Statistics in Medicine·Stephen Senn
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Gilda PiaggioUNKNOWN CONSORT Group
Sep 17, 2013·Scandinavian Journal of Medicine & Science in Sports·L DonathL Zahner

❮ Previous
Next ❯

Citations

Mar 11, 2020·Journal of Sports Sciences·Kym Joanne PriceAmanda Clare Benson
Mar 14, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Karen J Sherman
Nov 30, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Hashim IslamBrendon J Gurd
Jul 25, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Fabian HeroldNotger G Müller
Nov 2, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Yael NetzGal Ziv
May 20, 2020·Frontiers in Public Health·Marciele Alves BologneseBraulio Henrique Magnani Branco
Jan 28, 2021·Current Oncology·Amanda WurzS Nicole Culos-Reed
Feb 10, 2021·Medicine and Science in Sports and Exercise·Todd A Astorino
Apr 9, 2021·European Journal of Applied Physiology·Nicholas PreobrazenskiBrendon J Gurd
May 26, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Melanie Kistler-FischbacherBelinda R Beck
Jun 25, 2020·Journal of Sport and Health Science·Jozo GrgicPavle Mikulic
Jan 25, 2022·Clinical Physiology and Functional Imaging·Yujiro YamadaJeremy P Loenneke
Feb 4, 2022·Sports Medicine·Filipe Oliveira de AlmeidaCarla Silva-Batista

❮ Previous
Next ❯

Software Mentioned

RE
CONSORT
AIM Sports Setting
CONSORT Reporting Template ( CERT
- AIM
AIM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.