How to eliminate taeniasis/cysticercosis: porcine vaccination and human chemotherapy (Part 2)

Theoretical Biology & Medical Modelling
Norma Y Sánchez-TorresMarco V José

Abstract

The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the feasibility of interrupting the parasite's life cycle in endemic areas. A mathematical model that divides the population into susceptible, infected, and vaccinated individuals is formulated. The model is based upon the life cycle of the parasite. Computer numerical simulation experiments to evaluate the impact of pig vaccination under different vaccination schedules, and combined intervention strategies including pig vaccination and anthelmintic treatment against human taeniasis are carried out. Vaccination against either pig cysticercosis or against human taeniasis will influence the transmission dynamics not only among vaccinees but also the dynamics of the other hosts as well. When the protective efficacy and/or the coverage rate is less than 100%, different mass interventions like vaccinating the pig population twice in combination with chemotherapeutic treatment against human taeniasis, the elimination of the infection in both pigs and humans can also be achieved. Our mathematical model has the potential for planning, and designing effective intervention strategies including bot...Continue Reading

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Citations

Sep 19, 2020·PLoS Neglected Tropical Diseases·Noromanana Sylvia RamiandrasoaDavidra Rajaonatahina
Mar 7, 2020·Bulletin of the World Health Organization·Matthew A DixonMaria-Gloria Basáñez
May 29, 2020·Clinical Microbiology Reviews·Hector H GarciaRobert H Gilman
Jul 28, 2020·Parasites & Vectors·Ian W PrayUNKNOWN Cysticercosis Working Group in Peru
Aug 18, 2020·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·G K MeghaB B Singh
Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Valeria A SanderMarina Clemente
Aug 28, 2020·Journal of Molecular Graphics & Modelling·Ponciano García-GutiérrezAbraham Landa
May 28, 2021·Frontiers in Veterinary Science·Caitlin ButalaSusan Christina Welburn

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Software Mentioned

Mathematica
Matlab
NDSolve

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