How to handle borderline/precursor thyroid tumors in management of patients with thyroid nodules

Gland Surgery
Kennichi Kakudo

Abstract

Thyroid carcinomas originating from follicular cells have the prognosis of heterogeneous diseases, but pathologists classify them all as malignant disease. Epidemiologists have issued a stern warning regarding over-diagnosis and overtreatment of patients with indolent thyroid tumors that cause no harm to the patients. Review of the literature revealed that there were several proposals of borderline/precursor tumors to some indolent thyroid carcinomas. Thyroid tumor of uncertain malignant potential (UMP) was first proposed by Williams for encapsulated follicular pattern thyroid tumors to solve problems due to observer variation. Rosai et al. proposed to rename papillary microcarcinoma (PMC) to papillary micro-tumor as the overwhelming majority of them are of no clinical significance. Liu et al. proposed well-differentiated tumor with uncertain behavior (WDT-UB) which covered WDT of UMP (WDT-UMP) and non-invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). The EFVPTC without invasion was renamed as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) by an international panel of pathologists. A new prognostic classification of thyroid tumors was proposed by Kakudo et a...Continue Reading

Citations

Feb 14, 2019·International Journal of Cancer. Journal International Du Cancer·Sergei V Jargin
May 12, 2019·Diagnostic Pathology·Huanli DuanZhiyong Liang
Nov 3, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·K KakudoA Bychkov
Dec 12, 2018·Pathology International·Kennichi KakudoChan Kwon Jung
Oct 23, 2020·The Tohoku Journal of Experimental Medicine·Francesca MalettaMauro Papotti

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