How to make a fast diagnosis in invasive aspergillosis

Medical Mycology
Cornelia Lass-Flörl

Abstract

Aspergillosis is more common among immunocompromised patients with neutropenia or immunosuppression due to corticosteroid use, and infections are typically of the lung or sinuses. For diagnosis, broncholaveolar lavages (BALs) and lung biopsies are the specimens of choice. Culture and microscopic examinations are a must have and laboratory results should immediately be reported to the clinic. Fungal elements (hyphae) display the proof of an infection if present in primarily steril specimens, independent of culture results. Microscopy should be performed preferably using optical brighteners and histopathology using Gomori's methenamine silver stain or Periodic acid-Schiff. Serum and BAL galactomannan assays are recommended as markers for the diagnosis of invasive aspergillosis, PCR should be considered in conjunction with other diagnostic tests. Antifungal treatment decreases GM sensitivity. Pathogen identification to species complex level is strongly recommended for all clinically relevant Aspergillus isolates.

References

Mar 17, 2015·The Lancet Infectious Diseases·Silke SchelenzUNKNOWN British Society for Medical Mycology
Dec 25, 2015·The European Respiratory Journal·David W DenningUNKNOWN European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Nov 12, 2016·Methods in Molecular Biology·Cornelia Lass-Flörl
Jun 7, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Lass-Florl
Jul 7, 2017·Current Fungal Infection Reports·Sven Heldt, Martin Hoenigl
Mar 17, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A J UllmannO A Cornely
Apr 13, 2018·Frontiers in Microbiology·Tamara ZoranMichaela Lackner

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Citations

Aug 28, 2020·Expert Review of Respiratory Medicine·Stanca-Patricia HogeaCristian Oancea
Dec 6, 2020·Journal of Tropical Pediatrics·Buyun ShiHui Xu
Oct 15, 2020·Journal of Fungi·Jeffrey D JenksUNKNOWN European Confederation of Medical Mycology (ECMM) Council Investigators
Feb 19, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Cornelia Lass-FlörlMiriam Knoll
May 26, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Verena C ObmannAndreas Christe
May 27, 2021·Studies in Mycology·A ArastehfarM Hoenigl
Jul 26, 2021·La Revue de médecine interne·K ChevalierJ Lebut

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.