How to Make an Immune System and a Foreign Host Quickly Cohabit in Peace? The Challenge of Acute Graft-Versus-Host Disease Prevention After Allogeneic Hematopoietic Cell Transplantation.

Frontiers in Immunology
Benoît VandenhoveSophie Servais

Abstract

Allogeneic hematopoietic cell transplantation (alloHCT) has been used as cellular immunotherapy against hematological cancers for more than six decades. Its therapeutic efficacy relies on the cytoreductive effects of the conditioning regimen but also on potent graft-versus-tumor (GVT) reactions mediated by donor-derived immune cells. However, beneficial GVT effects may be counterbalanced by acute GVHD (aGVHD), a systemic syndrome in which donor immune cells attack healthy tissues of the recipient, resulting in severe inflammatory lesions mainly of the skin, gut, and liver. Despite standard prophylaxis regimens, aGVHD still occurs in approximately 20-50% of alloHCT recipients and remains a leading cause of transplant-related mortality. Over the past two decades, advances in the understanding its pathophysiology have helped to redefine aGVHD reactions and clinical presentations as well as developing novel strategies to optimize its prevention. In this review, we provide a brief overview of current knowledge on aGVHD immunopathology and discuss current approaches and novel strategies being developed and evaluated in clinical trials for aGVHD prevention. Optimal prophylaxis of aGVHD would prevent the development of clinically signi...Continue Reading

References

Mar 1, 1977·Journal of the National Cancer Institute·D W van Bekkum, S Knaan
Feb 1, 1974·Journal of the National Cancer Institute·D W van BekkumD van der Waaij
Nov 9, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·B J ChenN J Chao
Aug 7, 2002·The Journal of Experimental Medicine·José L CohenBenoît L Salomon
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jul 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pascale LoiseauColette Raffoux
May 21, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Leo LuznikEphraim J Fuchs
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mehdi HamadaniSteven M Devine
Jan 30, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Frédéric BaronYves Beguin
Apr 10, 2010·Current Topics in Microbiology and Immunology·Nicolai A Kittan, Gerhard C Hildebrandt
Oct 12, 2010·Science·Yuri P RubtsovAlexander Y Rudensky
Mar 9, 2011·Bone Marrow Transplantation·R M SalibaA M Alousi
Nov 24, 2011·Advances in Hematology·Jason R WestinDaniel R Couriel
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Isao TawaraPavan Reddy

❮ Previous
Next ❯

Citations

Jan 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qichao HuYanling Zhao

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Clinical Trials Mentioned

NCT04088760
NCT02508038
NCT02999854
NCT03945591
NCT03082677
NCT01991301
NCT02145403
NCT02867800
NCT01743131
NCT04380740

Software Mentioned

PTCy

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.