How to prevent alcoholic liver disease

Experimental and Molecular Pathology
S W French

Abstract

Betaine supplements of alcoholic beverages are proposed to prevent the development of alcoholic liver disease in patients that abuse alcohol. This recommendation is based on the observation of studies where it has been shown in binge drinking and chronic ethanol feeding animal models that betaine prevents liver injury resulting from high blood alcohol levels. The basic observation is that betaine added to ethanol being ingested increases the elimination rate of blood alcohol, which prevents the blood alcohol levels (BALs) from reaching high levels. The mechanism of how betaine does this is postulated to be that betaine causes the increase in the elimination rate by increasing the metabolic rate which generates NAD the rate limiting cofactor of alcohol oxidation by ADH. Betaine does this most likely by supporting the methylation of norepinephrine to form epinephrine by phenylethanolamine N-methyltransferase. Epinephrine is 5 to 10-fold more active than norepinephrine in increasing the metabolic rate.

References

Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·T YukiR G Thurman
Aug 15, 2001·Experimental and Molecular Pathology·J LiS W French
Oct 28, 2004·Experimental and Molecular Pathology·J LiSamuel W French
Jun 14, 2006·Experimental and Molecular Pathology·Fawzia Bardag-GorceSamuel W French
Jan 28, 2009·Alcoholism, Clinical and Experimental Research·F Bardag-GorceSamuel W French
Oct 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal F AbdelmalekKeith D Lindor
May 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vijay H Shah
Mar 1, 2011·Experimental and Molecular Pathology·Joan OlivaSamuel W French
Aug 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu-Sheng WangHong-Yang Wang

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Citations

Sep 8, 2015·Experimental and Molecular Pathology·Manuela G NeumanSamuel W French
Feb 7, 2016·Biochimica Et Biophysica Acta·Christopher R Day, Stephen A Kempson
Nov 3, 2020·World Journal of Gastroenterology : WJG·Sandeep Mukherjee
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Xiao MengHua-Bin Li
Nov 25, 2021·European Journal of Nutrition·Aisha Rehman, Kosha J Mehta

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