Mar 9, 2019

How to rebuild the kidney: recent advances in kidney organoids

Journal of Biochemistry
Mazharul Islam, Ryuichi Nishinakamura

Abstract

It is difficult to restore kidney function once it has become severely impaired. Although kidney transplantation is a curative therapy, donor numbers remain limited. Thus, the generation of kidney organoids (mainly comprising glomeruli and renal tubules) from multipotent stem cells represents an important advance in regenerative medicine of the kidney. Recently, a protocol that can generate the higher-order structure of the mouse embryonic kidney was reported. Kidney organoids are now being used for disease modelling, and may eventually be applicable for clinical transplantation. In this review, we summarize the recent advances in kidney organoid research, and discuss the issues to be resolved toward kidney reconstruction.

  • References26
  • Citations4

Citations

Mentioned in this Paper

Research
Regenerative Medicine
Kidney Reconstruction
Renal Tubule Structure
Kidney
Mouse Embryonic Stem Cells
Multipotent Stem Cells
Structure
Curative - Procedure Intent
Organ Transplantation

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