PMID: 2495911May 1, 1989Paper

How to select patients with deep vein thrombosis for tPA therapy

Chest
W D Brown, Samuel Z Goldhaber

Abstract

Despite enthusiasm for using thrombolytic therapy to treat proximal deep venous thrombosis (DVT), the proportion of patients eligible for this therapeutic strategy is unknown. Therefore, we screened all patients at Brigham and Women's Hospital who underwent leg venography in 1987. Of 240 patients with suspected DVT, 87 (36%) had positive venograms. Of those with positive venograms, 72 (83%) had proximal DVT, and 15 (17%) had DVT limited to calf veins. Overall, 22% of patients with proximal DVT were eligible for thrombolytic therapy. The major exclusion criteria were: (1) recent trauma or surgery, (2) recent GI bleeding, and (3) history of a bleeding disorder. Thus, thrombolytic therapy could be given to approximately one-fifth of our patients with proximal DVT.

Citations

Oct 12, 2000·Journal of the American College of Cardiology·J SchweizerA Graf
May 25, 2012·International Journal of Critical Illness and Injury Science·Sanjith Saseedharan, Sunil Bhargava
Sep 10, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Elsharawy, E Elzayat
May 28, 2010·The Mount Sinai Journal of Medicine, New York·Robert A Lookstein, Christopher F Giordano

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