How to stratify patients at risk for resistant bugs in skin and soft tissue infections?

Current Opinion in Infectious Diseases
Cristina Vazquez Guillamet, Marin H Kollef

Abstract

This article describes the strategies for stratifying patients with skin and soft tissue infections (SSTIs) according to their risk for infection with multidrug-resistant (MDR) pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) now represents the main cause in a variety of serious SSTIs. Risk factors for MRSA are constantly evolving and the distinction between community-acquired MRSA and hospital-acquired MRSA is becoming less clear from a therapeutic standpoint because of overlapping susceptibility patterns. Given these observations, physicians should be aware that directed empirical coverage of MRSA for serious SSTIs should be required in communities where this resistant pathogen is recognized to be a prevalent cause of infection. Similarly, other MDR bacteria are demonstrating alarming trends as causative pathogens in SSTIs. Pseudomonas aeruginosa, Acinetobacter species, and vancomycin-resistant Enterococcus can play an important role in polymicrobial long-standing infections such as diabetic foot infection and decubiti, but are also increasingly recognized in monomicrobial SSTIs. SSTIs caused by MDR bacteria, both Gram-positive and Gram-negative bacteria, are on the rise especially in patients with long-standing ...Continue Reading

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Citations

Mar 10, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·S S Almarzoky AbuhussainD P Nicolau
Jan 17, 2019·Current Opinion in Infectious Diseases·Paola Del GiacomoMario Tumbarello
Apr 9, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yoav Golan
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Jan 12, 2021·World Journal of Microbiology & Biotechnology·Ramita TaggarDebendra K Sahoo
Mar 23, 2021·Frontiers in Medicine·Michael ThyPhilippe Montravers

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Methods Mentioned

BETA
biopsies
16S sequencing

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