How to use nasal nitric oxide in a child with suspected primary ciliary dyskinesia

Archives of Disease in Childhood. Education and Practice Edition
Kim Simpson, Malcolm Brodlie

Abstract

Measuring nasal nitric oxide (nNO) is increasingly used as part of testing for primary ciliary dyskinesia (PCD). The diagnosis of PCD is often delayed until after bronchiectasis is established and auditory damage has occurred. It is important that all paediatricians are aware of clinical features that are suggestive of PCD that should prompt diagnostic testing. nNO levels are recognised to be low in people with PCD and results generated by static chemiluminescence analysers using velum closure technique in older children have good sensitivity and specificity. However, to conclusively rule PCD in or out, further tests of ciliary function are required and assessment of cilia ultrastructure, immunohistochemistry studies and genotyping may also be indicated. These tests are more complex, invasive and expensive than nNO. nNO is less well studied in younger children where tidal breathing measurements are required. Portable nitric oxide analysers are also increasingly used in practice. This paper discusses when to consider PCD as a possible diagnosis in a child along with the indications, physiological and technical background and clinical utility of nNO as a test for PCD in children.

References

Nov 2, 2004·The European Respiratory Journal·E BaraldiF Zacchello
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Sep 2, 2009·Archives of Disease in Childhood·C O'CallaghanE Moya
Dec 31, 2009·BMJ : British Medical Journal·Malcolm Brodlie, Michael C McKean
Jun 8, 2010·The European Respiratory Journal·J K Marthin, K G Nielsen
Jun 10, 2010·The European Respiratory Journal·C E KuehniUNKNOWN ERS Task Force on Primary Ciliary Dyskinesia in Children
Jul 24, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J Ulrich SommerBoris A Stuck
Mar 13, 2012·The European Respiratory Journal·Woolf T WalkerJane S Lucas
Feb 11, 2014·BMC Pulmonary Medicine·Amanda HarrisJane S Lucas
Feb 27, 2014·American Journal of Respiratory and Critical Care Medicine·Michael R KnowlesMaimoona A Zariwala
Apr 29, 2014·Archives of Disease in Childhood·Jane S LucasUNKNOWN National PCD Service, UK
Oct 18, 2014·The European Respiratory Journal·Samuel A CollinsJane S A Lucas
Mar 4, 2015·Pediatric Pulmonology·Nicole BeydonMuriel Le Bourgeois
Dec 10, 2015·The European Respiratory Journal·Claire L JacksonJane S Lucas
Feb 27, 2016·The European Respiratory Journal·Laura BehanJane S Lucas
Nov 12, 2016·The European Respiratory Journal·Jane S LucasClaudia E Kuehni

❮ Previous
Next ❯

Citations

Aug 5, 2018·Archives of Disease in Childhood. Education and Practice Edition·Rebecca Amy Dalrymple, Priti Kenia
Jul 30, 2019·Minerva pediatrica·Maria Grazia PappalardoSalvatore Leonardi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
A Moreno GaldóR Busquets Monge
Annals of the American Thoracic Society
Margaret W LeighMichael R Knowles
© 2022 Meta ULC. All rights reserved