How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews.

BMC Palliative Care
Bee WeeSheena Derry

Abstract

In contemporary medical research, randomised controlled trials are seen as the gold standard for establishing treatment effects where it is ethical and practical to conduct them. In palliative care such trials are often impractical, unethical, or extremely difficult, with multiple methodological problems. We review the utility of Cochrane reviews in informing palliative care practice. Published reviews in palliative care registered with the Cochrane Pain, Palliative and Supportive Care Group as of December 2007 were obtained from the Cochrane Database of Systematic Reviews, issue 1, 2008. We reviewed the quality and quantity of primary studies available for each review, assessed the quality of the review process, and judged the strength of the evidence presented. There was no prior intention to perform any statistical analyses. 25 published systematic reviews were identified. Numbers of included trials ranged from none to 54. Within each review, included trials were heterogeneous with respect to patients, interventions, and outcomes, and the number of patients contributing to any single analysis was generally much lower than the total included in the review. A variety of tools were used to assess trial quality; seven reviews di...Continue Reading

References

Mar 1, 1992·Journal of Clinical Epidemiology·A S DetskyK A L'Abbé
Jan 1, 1991·Journal of Clinical Epidemiology·A D Oxman, G H Guyatt
Feb 1, 1990·Journal of Pain and Symptom Management·J BlanchardJ Hoffman
Sep 1, 1989·Journal of Pain and Symptom Management·S VijayaramB Lobo
Mar 4, 1995·BMJ : British Medical Journal·G RinckC H Veenhof
Dec 24, 1994·BMJ : British Medical Journal·C E CounsellP A Sandercock
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G C RinckC H Veenhof
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·H J McQuayR A Moore
Aug 24, 1999·BMJ : British Medical Journal·I J Higginson
Mar 16, 2000·Palliative Medicine·G E Grande, C J Todd
May 5, 2000·The Cochrane Database of Systematic Reviews·D J Feuer, K E Broadley
May 5, 2000·The Cochrane Database of Systematic Reviews·H J McQuayR A Moore
Jun 22, 2000·The New England Journal of Medicine·K Benson, A J Hartz
Nov 18, 2000·American Journal of Ophthalmology·K Benson, A J Hartz
Jun 16, 2001·Palliative Medicine·C MazzocatoE Bruera
Jul 7, 2001·BMJ : British Medical Journal·P JüniM Egger
Nov 1, 2001·The Cochrane Database of Systematic Reviews·A L JenningsK Broadley
Jun 22, 2002·The Cochrane Database of Systematic Reviews·R Wong, P J Wiffen
Aug 15, 2002·Annals of the Rheumatic Diseases·P GeborekUNKNOWN South Swedish Arthritis Treatment Group
Oct 29, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I G FinlayC E Normand
Jan 10, 2003·The Cochrane Database of Systematic Reviews·A Hirst, R Sloan
Jan 22, 2003·The Cochrane Database of Systematic Reviews·R BellE Kalso
Sep 12, 2003·Journal of Pain and Symptom Management·Rae F BellEija Kalso
Oct 30, 2003·The Cochrane Database of Systematic Reviews·M RoquéM Ferrandiz
Oct 30, 2003·The Cochrane Database of Systematic Reviews·P J WiffenH J M McQuay
Feb 20, 2004·The Cochrane Database of Systematic Reviews·P Shaw, R Agarwal
Feb 20, 2004·The Cochrane Database of Systematic Reviews·K C Jackson, A G Lipman
Apr 24, 2004·The Cochrane Database of Systematic Reviews·D FellowesS Wilkinson
Apr 24, 2004·The Cochrane Database of Systematic Reviews·A B Nicholson
Apr 24, 2004·The Cochrane Database of Systematic Reviews·K C Jackson, A G Lipman
May 8, 2004·Journal of Palliative Medicine·G Gazelle, P G Fine
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ewan McNicolDaniel Carr
Jun 29, 2004·Current Opinion in Pulmonary Medicine·Sophie D WestY C Gary Lee
Jul 22, 2004·The Cochrane Database of Systematic Reviews·N AhmedS Paz
Jul 22, 2004·The Cochrane Database of Systematic Reviews·C Quigley
Oct 12, 2004·British Dental Journal·J BardenR A Moore
Jan 18, 2005·The Cochrane Database of Systematic Reviews·J C Ballantyne, C M Carwood
Jan 18, 2005·The Cochrane Database of Systematic Reviews·E McNicolD B Carr
Apr 23, 2005·The Cochrane Database of Systematic Reviews·E G Berenstein, Z Ortiz
Jun 14, 2005·Cancer Treatment Reviews·May N TsaoUNKNOWN Supportive Care Guidelines Group of Cancer Care Ontario's Program in Evidence-based Care
Oct 13, 2005·Palliative Medicine·Samar M Aoun, Linda J Kristjanson
Jan 27, 2006·The Cochrane Database of Systematic Reviews·G Zeppetella, M D C Ribeiro
Apr 21, 2006·The Cochrane Database of Systematic Reviews·J M EzzoG Zhang
Jul 21, 2006·The Cochrane Database of Systematic Reviews·M J Martinez-ZapataE Català

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Citations

Oct 8, 2009·Journal of Palliative Medicine·Wendy G AndersonRobert M Arnold
Mar 29, 2014·BMC Health Services Research·Tim LuckettPatricia M Davidson
May 14, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Irenäus A AdamietzHorst Sack
Dec 25, 2010·Der Internist·J GaertnerR Voltz
Mar 20, 2009·Journal of Pain & Palliative Care Pharmacotherapy·Ulf E Kongsgaard, Mads U Werner
Jun 6, 2009·Journal of Pain & Palliative Care Pharmacotherapy·Gina HadleyBee Wee
Sep 8, 2011·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Janet L WaleSita L Vij
Aug 31, 2010·International orthodontics·Marie DelièreJean-Noël Vergnes
Jun 21, 2014·BMJ Supportive & Palliative Care·Iain Harris, Scott A Murray
Nov 17, 2016·The Cochrane Database of Systematic Reviews·Waldemar SiemensGerhild Becker
Jun 13, 2017·The Cochrane Database of Systematic Reviews·Markus W HaunMechthild Hartmann
Nov 3, 2015·The Cochrane Database of Systematic Reviews·Lalage CoxSaskie Dorman
May 20, 2015·The Cochrane Database of Systematic Reviews·Alex MolassiotisJing-Yu Tan
May 25, 2010·European Journal of Heart Failure·Edward J DaviesRod S Taylor
Aug 28, 2018·International Journal of Evidence-based Healthcare·Hanan Khalil, Eli Ristevski
Sep 4, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·UNKNOWN ACPGBI Parastomal Hernia Group
Jun 17, 2009·Current Opinion in Supportive and Palliative Care·Velia A Löbbe
Apr 4, 2019·Journal of Water and Health·Kevin WelchShelley Zansky
Jun 18, 2009·Diabetes, Obesity & Metabolism·J PolisenaK Palmer
Mar 15, 2015·The Journal of the Association of Nurses in AIDS Care : JANAC·Graeme DonaldPaul Flowers
Nov 14, 2018·Health & Social Care in the Community·Beth StoneAilsa Cameron
Feb 9, 2012·BJU International·Marco OderdaPaolo Gontero
Mar 13, 2012·Health & Social Care in the Community·Juping Yu
Jun 20, 2012·Journal of Advanced Nursing·Claire Smith, Alistair Hewison
Aug 31, 2012·The American Journal of Clinical Nutrition·Mu ChenFrank B Hu
Mar 7, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Rebecca LovellMichael H Depledge
May 21, 2014·Worldviews on Evidence-based Nursing·David A RichardsUNKNOWN REFLECTION review team
Aug 6, 2019·Frontiers in Medicine·Carla TorreAna Paula Martins
Mar 11, 2019·Nursing Forum·Leodoro J LabragueKonstantinos Tsaras
Jan 30, 2015·The Cochrane Database of Systematic Reviews·Anita GrossUNKNOWN Cervical Overview Group

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