How useful is selection based on alarm symptoms in requesting gastroscopy? An evaluation of diagnostic determinants for gastro-oesophageal malignancy

Scandinavian Journal of Gastroenterology
M E NumansR A de Melker

Abstract

To derive and evaluate diagnostic determinants of gastro-oesophageal malignancy as a means of helping family physicians select patients for 'open-access' gastroscopy. In this multicenter study, 861 consecutive patients were investigated with first-time gastroscopy (study population). Another 1153 patients were studied during the next 6 years (validation population). General practitioners registered symptoms relevant to malignancy and patient histories; the results of gastroscopies were received from the endoscopists. Univariate and multivariate analyses resulted in four relevant symptoms that were then compared with 'alarm symptoms' previously published in the literature. Receiver-operating characteristic analysis was used to evaluate the probability of finding malignancy using these two sets of symptoms. Positive answers regarding the symptoms, weight loss and dysphagia, together with negative answers on pain during the night and heartburn, predicted malignancy in the study population with an AUC (area under the curve) of 0.90. 'Alarm symptoms' performed less well in the study population (AUC 0.85), although reproducibility was better in the validation population (0.71 versus 0.63). If exclusion of malignancy had been chosen a...Continue Reading

References

Dec 1, 1992·Family Practice·Y T Van der SchouwJ H Ruijs
Jul 1, 1990·Scandinavian Journal of Gastroenterology·T JohannessenH Waldum
Aug 15, 1995·Annals of Internal Medicine·A M FendrickB S Bloom
Apr 1, 1997·Gastroenterology·A T Axon

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Citations

Aug 26, 2010·The British Journal of Surgery·E RhatiganJ N Plevris
Nov 12, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H M Y MudawiS Z Ibrahim
Nov 16, 2005·Gastroenterology·Nicholas J TalleyPaul Moayyedi
Oct 13, 2006·Current Opinion in Gastroenterology·J A Louw, I N Marks
Dec 1, 2004·Alimentary Pharmacology & Therapeutics·G A J FransenJ B M J Jansen
Oct 22, 2008·Scandinavian Journal of Gastroenterology·Maarit SaloKatri Kaukinen
Sep 29, 2015·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Margaret P AstinWilliam Hamilton
Apr 28, 2005·Alimentary Pharmacology & Therapeutics·J M MasonUNKNOWN North of England Dyspepsia Guideline Development Group
Jun 29, 2004·Journal of Clinical Gastroenterology·Robert J F LaheijJan B M J Jansen
Oct 30, 2004·Scandinavian Journal of Gastroenterology·N J TalleyL Agréus
Nov 20, 2020·Therapeutic Advances in Gastroenterology·Judith J de JongJoost P H Drenth

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