[How useful is the combination of B vitamins and analgesic agents?].

Der Schmerz
I Jurna, P W Reeh

Abstract

Vitamins of the B group have long been used to treat neuropathies of different origins and the accompanying pain. A combination of the vitamins B(1), B(6), and B(12) prevents the slowing of impulse conduction produced by tetanic stimulation in diabetic mice. In patients suffering from diabetic neuropathy, B vitamins alleviate pain in the upper extremities. Thermosensitivity is restored by B vitamins in the upper but not in the lower extremities. It has recently also been reported that a combination of the vitamins B1, B6, and B12 has analgesic properties in non-neuropathic conditions. In animal experiments, B vitamins diminish nociceptive responses in spinal and thalamic neurones and potentiate the antinociceptive effect of analgesic agents. Similarly, B vitamins potentiate the therapeutic effect of diclofenac in patients suffering from acute low back pain.

References

Jan 19, 1990·Klinische Wochenschrift·K DakshinamurtiD Bonke
Dec 19, 1988·Neuroscience Letters·Q G FuM Zimmermann
Jul 1, 1986·Journal of Vascular Surgery·D B McNamaraM D Kerstein

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