How we diagnose and treat neutropenia in adults

Expert Review of Hematology
Jan PalmbladHelen A Papadaki

Abstract

Neutropenias (NPs), being acute and often transient, or chronic, range from life-threatening conditions with very low absolute neutrophil blood counts (ANC) to disorders characterized by only mild NP and of no obvious significance for health. Many are caused by genetic variations/mutations, e.g. the benign familial NP and the chronic severe NPs (e.g. Kostmann disease). Some of the latter are associated with various bodily malformations. Many of the mild-to-moderate NPs are signs of underlying disorders that need specialized treatments (e.g. HIV, hepatitis, autoimmune disorders, the large granular lymphocyte syndrome). We provide here means for the evaluation of a previously unknown NP, suggest a triage and treatments.

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Citations

Nov 15, 2016·Current Opinion in Hematology·David C Dale, Audrey A Bolyard
Dec 4, 2016·Hematology·Peter E Newburger
Feb 7, 2018·Transfusion·Tomohiro YabushitaTakayuki Ishikawa
Nov 21, 2018·American Journal of Hematology·Piero FarruggiaCarlo Dufour
May 7, 2019·Microsystems & Nanoengineering·Abbas FurniturewallaMehdi Javanmard
May 22, 2021·Pharmacological Reviews·Samantha Christine SernoskieJack Paul Uetrecht
Jul 7, 2021·Revista de psiquiatrí́a y salud mental·Gabriel VallecilloVictor Pérez

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