How we manage Philadelphia-negative myeloproliferative neoplasms in pregnancy

British Journal of Haematology
Susan E Robinson, Claire Harrison

Abstract

The combined incidence of classical Philadelphia-negative myeloproliferative neoplasm (MPN) is 6-9/100 000 with a peak frequency between 50 and 70 years. MPN is less frequent in women of reproductive age. However, for essential thrombocythaemia (ET) in particular there is a second peak in women of reproductive age and 15% of polycythaemia vera (PV) patients are less than 40 years of age at the time of diagnosis. Thus these diseases are encountered in women of reproductive potential and may be diagnosed in pregnancy or in women being investigated for recurrent pregnancy loss. The incidence of MPN pregnancies is 3·2/100 000 maternities per year in the UK. The majority of data regarding Philadelphia-negative MPNs relates to patients with ET, for which the literature suggests significant maternal morbidity and poor fetal outcome; specifically maternal thrombosis and haemorrhage, miscarriage, pre-eclampsia, intrauterine growth restriction (IUGR), stillbirth and premature delivery as summarised in the recent systematic review and meta-analysis in Blood, 2018, 132, 3046. The literature for PV is more sparse but increasing and is concordant with ET pregnancy outcomes. The literature regarding primary myelofibrosis (PMF) is even more sc...Continue Reading

References

Apr 1, 1987·Jikken dobutsu. Experimental animals·Y Asano, A Okaniwa
Apr 1, 1973·Teratology·R E ButcherE J Ritter
Nov 1, 1983·Journal of Pharmacobio-dynamics·M IwamaY Mori
Jan 1, 1981·Clinical Pediatrics·J H Clark, W G Wilson
Jul 1, 1994·American Journal of Hematology·M Pérez-EncinasS Tome
Jan 1, 1993·Clinical and Laboratory Haematology·A J Balloch, M N Cauchi
Sep 1, 1996·Leukemia & Lymphoma·M GriesshammerT C Pearson
Dec 3, 1999·Journal of Internal Medicine·M L RandiA Girolami
Jun 28, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·R CincottaS P Brennecke
Sep 28, 2000·European Journal of Haematology·M BangerterM Griesshammer
Dec 29, 2000·Annals of Medicine·E Van De Graaff, S R Steinhubl
May 15, 2001·European Journal of Haematology·C A Wright, A Tefferi
Jan 9, 2004·The New England Journal of Medicine·Raffaele LandolfiUNKNOWN European Collaboration on Low-Dose Aspirin in Polycythemia Vera Investigators
Nov 4, 2004·European Journal of Haematology·Riitta NiittyvuopioTapani Ruutu
Apr 22, 2005·British Journal of Haematology·Claire Harrison
Nov 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elisa RumiMario Lazzarino
Mar 12, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jeltsje S CnossenKhalid S Khan
Jul 12, 2008·Blood Reviews·Martin GriesshammerTiziano Barbui
Feb 27, 2009·European Journal of Haematology·Naseema GangatAyalew Tefferi
Aug 26, 2009·American Journal of Hematology·Lorella MelilloLuigi Gugliotta
Apr 2, 2010·Archives of Gynecology and Obstetrics·Neelam AggarwalPankaj Malhotra
Nov 26, 2010·Blood·Philip A BeerAnthony R Green
Nov 23, 2013·American Journal of Hematology·Maria Luigia RandiTiziano Barbui
Aug 8, 2015·Haematologica·Elisa RumiUNKNOWN Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·Shannon M BatesIan Greer
Feb 24, 2016·British Journal of Haematology·Alberto Alvarez-LarránUNKNOWN Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN)
Sep 10, 2016·British Journal of Haematology·Samah AlimamSusan Robinson
Apr 19, 2017·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Palika DattaThomas W Hale
Jun 29, 2017·The New England Journal of Medicine·Daniel L RolnikKypros H Nicolaides
Dec 12, 2017·Obstetric Medicine·Mathieu PuyadeOlivier Pourrat
Apr 15, 2018·Journal of Thrombosis and Thrombolysis·Amihai RottenstreichYosef Kalish
Jul 11, 2018·American Journal of Hematology·Irene BertozziMaria L Randi
Aug 8, 2018·Expert Review of Hematology·Martin GriesshammerKai Wille

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Citations

Oct 3, 2020·Annals of Hematology·Francesca PalandriLucia Catani
Aug 23, 2020·International Journal of Molecular Sciences·Alessandra IurloLuca Baldini
Oct 21, 2020·Expert Review of Hematology·Jan Philipp Bewersdorf, Amer M Zeidan
Dec 10, 2020·American Journal of Hematology·Naseema Gangat, Ayalew Tefferi
Nov 4, 2020·Journal of Cancer Research and Clinical Oncology·Lukas SchrickelUNKNOWN German Study Group MPN, GSG-MPN
Feb 23, 2021·Case Reports in Hematology·Yoshinori HashimotoTakayuki Tanaka
Mar 2, 2021·Hematology/oncology Clinics of North America·Andrew I Schafer
Apr 22, 2021·HemaSphere·Andrew J Robinson, Anna L Godfrey
Mar 26, 2021·European Journal of Haematology·Kai WilleMartin Griesshammer

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