How well do elderly patients with major depressive disorder respond to antidepressants: a systematic review and single-group meta-analysis

BMC Psychiatry
Katharina GutsmiedlStefan Leucht

Abstract

Depression is one of the leading causes of the global burden of disease, and it has particularly negative consequences for elderly patients. Antidepressants are the most frequently used treatment. We present the first single-group meta-analysis examining: 1) the response rates of elderly patients to antidepressants, and 2) the determinants of antidepressants response in this population. We searched multiple databases for randomized controlled trials on antidepressants in the elderly with major depressive disorder above 65 years (last search: December 2017). Response was defined as 50% improvement on validated rating scales. We extracted response rates from studies and imputed the missing ones with a validated method. Data were pooled in a single-group meta-analysis. Additionally, several potential moderators of response to antidepressants were examined by subgroup and meta-regression analyses. We included 44 studies with a total of 6373 participants receiving antidepressants. On average, 50.7% of the patients reached a reduction of at least 50% on the Hamilton Depression Scale (HAMD). Subgroup and meta-regression analyses revealed a better response to treatment for patients in antidepressant-controlled trials compared to placeb...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1992·Journal of General Internal Medicine·G W DivineL M Frazier
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 18, 1998·Journal of Affective Disorders·N MittmannN H Shear
Jun 6, 2000·Archives of General Psychiatry·D C SteffensJ C Breitner
Mar 27, 2002·International Journal of Epidemiology·Diana R ElbourneAndy Vail
May 25, 2002·Journal of the American Geriatrics Society·David W OslinThomas TenHave
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Dec 17, 2004·International Clinical Psychopharmacology·Toshi A FurukawaNorio Watanabe
Jun 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hans-Ulrich Wittchen, Frank Jacobi
Sep 21, 2005·Journal of Clinical Pharmacology·Francis E Lotrich, Bruce G Pollock
Feb 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Dan V IosifescuMaurizio Fava
Feb 8, 2006·Postgraduate Medical Journal·R Peters
Mar 15, 2006·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Zhao-Xiang BianLisa Song
May 1, 2007·Aging Cell·Dara L DicksteinPatrick R Hof
Oct 16, 2007·Der Internist·C C Sieber
Nov 14, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Joel R SneedSteven P Roose
Jan 4, 2008·The American Journal of Psychiatry·George S AlexopoulosMatthew J Hoptman
Aug 30, 2008·Journal of Psychiatric Research·Elizabeth A YoungA John Rush
Jun 12, 2009·Drug Metabolism Reviews·Ulrich Klotz
May 24, 2011·Crisis·Sylvie LapierreUNKNOWN International Research Group for Suicide among the Elderly
Jan 17, 2012·The Journal of Clinical Psychiatry·Enrico TedeschiniGeorge I Papakostas
Dec 19, 2012·Journal of Affective Disorders·Raffaella CalatiAlessandro Serretti
Jan 16, 2013·The American Journal of Psychiatry·Bret R Rutherford, Steven P Roose
Jan 30, 2013·Journal of Affective Disorders·Stefan LeuchtArmin Szegedi
Dec 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michael RobinsonJ Craig Nelson
Mar 5, 2015·Expert Opinion on Drug Metabolism & Toxicology·Janet SultanaGianluca Trifirò
Apr 26, 2015·Journal of Affective Disorders·Yu HayasakaToshi A Furukawa
Apr 22, 2016·Journal of Psychopharmacology·David J Nutt, Pierre Blier
Oct 7, 2016·BMJ : British Medical Journal·Michael Woodhead
Jun 21, 2017·BMJ : British Medical Journal·Jane Parry
Jul 4, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yikang ZhuStefan Leucht
Sep 29, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Patrick J BrownBret R Rutherford
Oct 17, 2017·Journal of Affective Disorders·Stefan LeuchtArmin Szegedi
Jul 23, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marc KrauseStefan Leucht

❮ Previous
Next ❯

Software Mentioned

Comprehensive Meta - Analysis
Cochrane

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.