How well do vaccines for Bordetella bronchiseptica work in dogs? A critical review of the literature 1977-2014

The Veterinary Journal
John A Ellis

Abstract

Bordetella bronchiseptica (Bb) has long been causally associated with respiratory disease in dogs. Parenteral and intranasal vaccines for this pathogen have been in common use since their development in the late 1970s and early 1980s and recently a commercial oral Bb vaccine has become available. Overall, the literature (comprising experimental infection models and field studies) documents the efficacy of these vaccines in stimulating disease-sparing mucosal and systemic immune responses that can be associated with reduced growth of Bb in vivo. However, many of the published studies are limited by flaws in experimental design, most notably a failure to consider the biological and statistical implications of the 'pen effect'. Many questions related to the longevity of vaccine induced immunity against Bb and the impact of natural exposure on herd immunity remain unanswered.

References

May 1, 1977·The Journal of Infectious Diseases·D A BemisM J Appel
Jun 3, 1978·The Veterinary Record·I A McCandlishN G Wright
Feb 21, 1976·The Veterinary Record·I A McCandlishN G Wright
Sep 1, 1992·The Veterinary Clinics of North America. Small Animal Practice·D A Bemis
Jan 1, 1987·Journal of Biological Standardization·R K GuptaS N Saxena
Nov 3, 1973·The Veterinary Record·N G WrightH J Cornwell
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Feb 24, 2001·Journal of the American Veterinary Medical Association·J A EllisG Headrick
Jun 19, 2002·Preventive Veterinary Medicine·Janet E FoleyJoy Milan
Jun 9, 2009·Current Opinion in Immunology·Shan Lu
Jan 18, 2011·International Reviews of Immunology·Himanshu KumarShizuo Akira
Mar 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jennie S LavineOttar N Bjørnstad
Jul 31, 2012·Journal of the American Animal Hospital Association·William Buhles, Philip H Kass
Nov 28, 2012·Expert Review of Vaccines·Neha Dalmia, Alistair J Ramsay
Aug 26, 2014·Science·Hamid JafariR Bruce Aylward

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Citations

Jan 20, 2016·The Journal of Small Animal Practice·M J DayUNKNOWN Vaccination Guidelines Group (VGG) of the World Small Animal Veterinary Association (WSAVA)
May 12, 2015·The Veterinary Journal·Richard A Squires
Feb 26, 2020·International Journal of Molecular Sciences·Mateusz SzymczakPiotr Golec
Dec 10, 2019·The Veterinary Clinics of North America. Small Animal Practice·Krystle L Reagan, Jane E Sykes

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