How well does the CSF inform upon pathology in the brain in Creutzfeldt-Jakob and Alzheimer's diseases?

The Journal of Pathology
R O Weller

Abstract

Analysis of lumbar cerebrospinal fluid (CSF) plays a major role in the investigation of central nervous system disease, but how well do the changes in the CSF reflect pathology within the brain and spinal cord parenchyma? Both Creutzfeldt-Jakob (CJD) and Alzheimer's disease (AD) are characterized by the deposition of insoluble beta-pleated sheet peptides [prion protein (PrP) and beta-amyloid (Abeta), respectively] in the extracellular spaces of grey matter in the brain, but there is discordance in both diseases between the peptide levels in the brain and in the CSF. Experimental studies using tracers have shown that interstitial fluid (ISF) drains through very narrow intercellular spaces within grey matter into bulk flow perivascular channels that surround penetrating arteries. ISF then flows to the surface of the brain and joins CSF to drain to cervical lymph nodes. Such drainage of ISF and CSF to regional lymph nodes in the rat plays a significant role in B-cell and T-cell immune reactions within the brain. In man, the pia mater separates the periarterial ISF drainage pathways from the CSF in the subarachnoid space. The almost complete lack of insoluble protease-resistant PrP entering the CSF from the brain in patients with C...Continue Reading

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Citations

Oct 13, 2009·Analytical and Bioanalytical Chemistry·David SingerRalf Hoffmann
Dec 10, 2002·Neurobiology of Aging·H Michael Tucker, Steven Estus
Jun 24, 2010·BMC Neurology·Niklas MattssonLars Hagberg
Jul 13, 2016·Brain : a Journal of Neurology·Antoine LeuzyAgneta Nordberg
Jan 31, 2012·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Emil PalečekMojmír Trefulka
Nov 19, 2002·The Journal of Biological Chemistry·Thomas AntonyVinod Subramaniam
Mar 18, 2006·Drugs in R&D·Donna M BartenCharles F Albright
Dec 19, 2007·The Analyst·Emil PalecekThomas M Jovin
May 27, 2008·Veterinary Immunology and Immunopathology·Laura J VellaAndrew F Hill

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