How well does the Gleason score predict prostate cancer death? A 20-year followup of a population based cohort in Sweden

The Journal of Urology
Ove AndrénMark A Rubin

Abstract

Adenocarcinoma of the prostate is the most common cancer among men in Western countries. Although the prognostic heterogeneity of prostate cancer is enormous, clinically insignificant aggressive prostate cancers cannot be reliably distinguished. Therefore, identifying prognostic factors is increasingly important, notably among men diagnosed with localized prostate cancer, because many of them may not require aggressive treatment. We analyzed a population based cohort of 253 men with early stage (T1a-b, Nx, M0) initially untreated prostate cancer diagnosed between 1977 and 1991, before PSA screening was available. Tissue samples were available for 240 patients diagnosed with transurethral resection. During complete followup through September 2003, standardized criteria were used to classify histopathological characteristics, progression and causes of death. Higher Gleason grade, higher nuclear grade and larger tumor volume were independent predictors of death in prostate cancer with monotonous and statistically significant trends (p <0.05). In contrast, the level of Ki-67 - strongly correlated to Gleason score - was not an independent predictor of prostate cancer death. Given a Gleason score of 7 or greater, the probability of d...Continue Reading

References

Dec 1, 1988·The Journal of Urology·B A Lowe, M B Listrom
Aug 23, 1995·JAMA : the Journal of the American Medical Association·P C AlbertsenJ Fine
Feb 12, 1997·JAMA : the Journal of the American Medical Association·J E JohanssonH O Adami
Jun 8, 2000·Journal of the National Cancer Institute·E E PerroneM A Rubin
Apr 12, 2002·BJU International·L EgevadP Stattin
Sep 18, 2003·Journal of the National Cancer Institute·Howard M Sandler, Michelle L DeSilvio
May 28, 2004·The New England Journal of Medicine·H Ballentine Carter
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Jan-Erik JohanssonHans-Olov Adami
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Winkle KwanChuck Paltiel
May 13, 2005·The New England Journal of Medicine·Anna Bill-AxelsonUNKNOWN Scandinavian Prostate Cancer Group Study No. 4
Sep 8, 2005·The Journal of Urology·Patrick C Walsh

❮ Previous
Next ❯

Citations

Jul 21, 2011·Cancer Causes & Control : CCC·Wildon R FarwellJ Michael Gaziano
Oct 9, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sabina DavidssonJennifer R Rider
May 29, 2008·Journal of the National Cancer Institute·Sunita R SetlurMark A Rubin
May 29, 2007·The American Journal of Surgical Pathology·Sven PernerMark A Rubin
Dec 14, 2011·The Cancer Journal·Neil E MartinRonald A Depinho
Mar 27, 2012·Journal of Clinical Pathology·Christopher FioreRichard Flavin
Oct 30, 2007·Journal of Clinical Pathology·Francesca Demichelis, Mark A Rubin
Jun 28, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lorelei A MucciMark A Rubin
Oct 28, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn L PenneyMatthew L Freedman
Aug 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniel W LinJanet L Stanford
Sep 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabina DavidssonJennifer R Rider
Nov 6, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Irene M ShuiEdward Giovannucci
Apr 16, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathryn L PenneyMatthew L Freedman
Mar 4, 2011·Cancer Prevention Research·Mark M PomerantzMatthew L Freedman
Sep 16, 2009·BMC Medical Research Methodology·Joseph BeyeneLillian Sung
Mar 18, 2010·BMC Medical Genomics·Andrea SbonerOve Andrén
May 13, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer R StarkLorelei A Mucci
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn L PenneyLorelei A Mucci
Dec 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Youngho SeoRandall A Hawkins
May 15, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joseph H YacoubOto Aytekin
Dec 15, 2015·European Urology·Diego Iglesias-GatoAmilcar Flores-Morales
Jan 6, 2015·International Journal of Cancer. Journal International Du Cancer·Jaquelyn L JahnMeir J Stampfer
Aug 21, 2013·Journal of Experimental & Clinical Cancer Research : CR·Hongtuan ZhangYong Xu
Jul 25, 2015·BJU International·Brandon A MahalPaul L Nguyen
Mar 30, 2016·Cancer Causes & Control : CCC·Johan BrändstedtJohan Malm
Nov 6, 2007·BJU International·Daniel M BerneyUNKNOWN Trans-Atlantic Prostate Group
Jun 10, 2008·Cancer Cell·Scott A TomlinsArul M Chinnaiyan
Aug 6, 2015·PloS One·Athanasios TsalatsanisBenjamin Djulbegovic
Jul 6, 2016·Cancer Causes & Control : CCC·Meng YangEdward Giovannucci
Jan 1, 2011·Expert Opinion on Medical Diagnostics·Sofia HalinAnders Bergh
Mar 9, 2018·Case Reports in Oncology·Johannes C van der MijnAernout C Ogilvie
Dec 20, 2008·American Journal of Clinical Pathology·Peter A Humphrey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.