PMID: 15232407Jul 3, 2004Paper

How would a decline in sperm concentration over time influence the probability of pregnancy?

Epidemiology
Rémy SlamaN Keiding

Abstract

Reports have suggested a decline in sperm concentration during the second half of the 20th century. The effect of this decline on fecundability (the monthly probability of pregnancy) could be detected in principle by a study of time to pregnancy. In practice, the amplitude of this expected effect is not well known and the statistical power of time-to-pregnancy studies to detect it has not been explored. We developed a nonparametric model to describe a temporal decline in sperm concentration using data on French semen donors. We then applied this model to 419 Danish couples planning a first pregnancy in 1992, to predict their time to pregnancy as if the pregnancy attempt had begun during earlier decades with higher sperm concentrations. Finally, we used bootstrap simulations to estimate the statistical power of prospective or retrospective studies that compared fecundability (estimated from time to pregnancy) across these time periods. We express the change in fecundability over time as a fecundability ratio (FR), with values less than 1 indicating decreased fecundability. We estimate that the median sperm concentration decreased by 21% from 1977 to 1992 and by 47% from 1947 to 1992. The estimated decline in fecundability with t...Continue Reading

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Citations

May 12, 2009·Human Reproduction·M JoffeN Keiding
Nov 26, 2009·Human Reproduction·Michael Joffe
Apr 17, 2010·Human Reproduction·Egbert te VeldeDik Habbema
Jul 6, 2010·Human Reproduction·Benjamin N BreyerMichael L Eisenberg
Nov 26, 2009·Human Reproduction Update·Trevor G CooperKirsten M Vogelsong
Jul 7, 2010·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Feb 14, 2009·BMJ : British Medical Journal·Hazel M InskipUNKNOWN Southampton Women's Survey Study Group
Aug 4, 2004·Environmental Health Perspectives·Rémy SlamaJean Bouyer
Apr 12, 2013·Human Reproduction Update·David MortimerCharles H Muller
Apr 10, 2013·American Journal of Epidemiology·Rémy Slama
Jul 28, 2013·American Journal of Epidemiology·Michael JoffeNicky Best
Jun 14, 2005·Epidemiology·Markku SallménAllen J Wilcox
Jun 7, 2006·Epidemiology·Rémy SlamaJean Bouyer
Jan 29, 2008·Epidemiology·Thomas H ScheikeOlof Akre
Feb 4, 2010·Epidemiology·Brenda EskenaziPaolo Mocarelli
Nov 22, 2008·Fertility and Sterility·Caroline MoreauRémy Slama
Apr 13, 2006·Revue D'épidémiologie Et De Santé Publique·A MullerA Spira
Aug 15, 2006·Toxicology·Giuseppe LatiniClaudio De Felice
Nov 29, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dale BrincatJean Calleja-Agius
Sep 11, 2018·Epidemiology·Marinus J C EijkemansRémy Slama
Jan 15, 2005·Human Reproduction·Tina Kold JensenKaare Christensen
Oct 26, 2018·Reproductive Biology and Endocrinology : RB&E·Priyanka MishraSingh Rajender
Apr 18, 2006·Statistical Methods in Medical Research·Thomas H Scheike, Niels Keiding
Nov 27, 2018·Reproductive Biology and Endocrinology : RB&E·Alessandro IlacquaAntonio Aversa
Mar 9, 2007·Human Reproduction·C H Ramlau-HansenJ Olsen

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