Hox cofactors in vertebrate development

Developmental Biology
Cecilia B Moens, Licia Selleri

Abstract

Hox genes encode homeodomain-containing transcription factors that pattern the body axes of animal embryos. It is well established that the exquisite DNA-binding specificity that allows different Hox proteins to specify distinct structures along the body axis is frequently dependent on interactions with other DNA-binding proteins which act as Hox cofactors. These include the PBC and MEIS classes of TALE (Three Amino acid Loop Extension) homeodomain proteins. The PBC class comprises fly Extradenticle (Exd) and vertebrate Pbx homeoproteins, whereas the MEIS class includes fly Homothorax (Hth) and vertebrate Meis and Prep homeoproteins. Exd was first implicated as a Hox cofactor based on mutant phenotypes in the fly. In vertebrates, PBC and MEIS homeobox proteins play important roles in development and disease. In this review, we describe the evidence that these functions reflect a requirement for Pbx and Meis/Prep proteins as Hox cofactors. However, there is mounting evidence that, like in the fly, Pbx and Meis/Prep proteins function more broadly, and we also discuss how "Hox cofactors" function as partners for other, non-Hox transcription factors during development. Conversely, we review the evidence that Hox proteins have funct...Continue Reading

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A KennedyT H Rabbitts
Dec 1, 1991·Molecular and Cellular Biology·K MonicaM L Cleary
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R S Mann
Oct 1, 1995·Molecular and Cellular Biology·J J MoskowA M Buchberg
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S T NeuteboomC Murre
Aug 1, 1995·Current Opinion in Genetics & Development·D Duboule
Aug 1, 1995·Molecular and Cellular Biology·M L PhelanM S Featherstone
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B FavierP Dollé
Apr 21, 1994·Nature·C W RobertsS J Korsmeyer
Jul 29, 1994·Cell·R Krumlauf
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N DearT H Rabbitts
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T LufkinP Chambon
Mar 1, 1996·Nucleic Acids Research·W F ShenC Largman
Jul 25, 1996·Nature·C A LoomisA L Joyner
Nov 15, 1996·Science·A Lumsden, R Krumlauf
Jan 15, 1997·Developmental Biology·F Chen, M R Capecchi
Jan 1, 1997·Poultry Science·B A Morgan
Oct 29, 1997·Molecular and Cellular Biology·W F ShenC Largman

❮ Previous
Next ❯

Citations

Jun 15, 2013·Cellular and Molecular Life Sciences : CMLS·Cédric Francius, Frédéric Clotman
May 1, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·James A MacLean, Miles F Wilkinson
Oct 22, 2013·Cancer Chemotherapy and Pharmacology·Hitoshi AndoToshishiko Wakabayashi
Feb 25, 2014·Future Oncology·Etienne De BraekeleerMarc De Braekeleer
Mar 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Leila DardaeiFrancesco Blasi
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Samir MerabetYacine Graba
Feb 4, 2014·Scientifica·Ernesto Sánchez-Herrero
Sep 3, 2014·Micron : the International Research and Review Journal for Microscopy·Serena BarachiniMario Petrini
Jul 30, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fengliang WangCheng Lu
Sep 1, 2012·Annual Review of Genetics·Katherine M LelliRichard S Mann
Apr 17, 2014·Theory in Biosciences = Theorie in Den Biowissenschaften·Joseph E Hannon Bozorgmehr
Jul 20, 2007·BMC Developmental Biology·Curtis R FrenchAndrew J Waskiewicz
Sep 6, 2007·Molecular and Cellular Biology·Ke-Qin GongDeneen M Wellik
Dec 7, 2007·Genome Research·Philippe P LuediAlexander J Hartemink
Apr 22, 2008·ACS Chemical Biology·Rocco MorettiAseem Z Ansari
Jul 23, 2008·Molecular and Cellular Biology·Francesco OrienteFrancesco Beguinot
Nov 1, 2008·Reproductive Biology and Endocrinology : RB&E·Takayo OtaPeter C K Leung
Apr 15, 2009·PloS One·J Carlos VillaescusaFrancesco Blasi
Jan 8, 2010·BMC Evolutionary Biology·R Craig AlbertsonJohn H Postlethwait
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yan ZhangXiaojing Ma
Mar 3, 2010·Molecular Psychiatry·D E AdkinsE J C G van den Oord
Mar 12, 2010·BMC Cancer·Richard MorganHardev S Pandha
Apr 15, 2010·The Journal of Clinical Investigation·Penney M GilbertValerie M Weaver
May 5, 2010·Molecular and Cellular Biology·Jonathan A R GordonJane B Lian
Jul 17, 2010·Genes & Development·Rohit JoshiRichard Mann
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jiangying LiuDoris A Stoffers
Jul 13, 2011·Molecular and Cellular Biology·Glen A BjerkeDavid Wotton
Jul 14, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andreas ReifKlaus-Peter Lesch
Oct 1, 2011·PloS One·Stéphanie DelvalRené Rezsohazy

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.