Hox Function Is Required for the Development and Maintenance of the Drosophila Feeding Motor Unit

Cell Reports
Jana FriedrichIngrid Lohmann

Abstract

Feeding is an evolutionarily conserved and integral behavior that depends on the rhythmic activity of feeding muscles stimulated by specific motoneurons. However, critical molecular determinants underlying the development of the neuromuscular feeding unit are largely unknown. Here, we identify the Hox transcription factor Deformed (Dfd) as essential for feeding unit formation, from initial specification to the establishment of active synapses, by controlling stage-specific sets of target genes. Importantly, we found Dfd to control the expression of functional components of synapses, such as Ankyrin2-XL, a protein known to be critical for synaptic stability and connectivity. Furthermore, we uncovered Dfd as a potential regulator of synaptic specificity, as it represses expression of the synaptic cell adhesion molecule Connectin (Con). These results demonstrate that Dfd is critical for the establishment and maintenance of the neuromuscular unit required for feeding behavior, which might be shared by other group 4 Hox genes.

References

Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Feb 13, 2001·Neuron·S RajagopalanB J Dickson
Jun 5, 2002·Genome Research·W James KentDavid Haussler
Feb 19, 2004·Science's STKE : Signal Transduction Knowledge Environment·Sean E McGuireRonald L Davis
Aug 7, 2004·Science·Dave KosmanEthan Bier
Dec 13, 2005·Nature Reviews. Genetics·Joseph C PearsonWilliam McGinnis
Jul 25, 2006·Developmental Biology·Thorsten HadrysSilke Rinkwitz
Oct 20, 2007·Nature Reviews. Neuroscience·Sarah Guthrie
Nov 30, 2007·Developmental Neurobiology·Richa DixitMichael Bate
Apr 29, 2008·Neuron·Iris KochHermann Aberle
Jun 6, 2008·Current Opinion in Neurobiology·Simon A Dalla Torre di SanguinettoSilvia Arber
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Joshua R Sanes, Masahito Yamagata
Sep 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rudolf A BohmBing Zhang
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrea ManzoKristin Scott
Jul 12, 2012·The EMBO Journal·Sebastian SorgeIngrid Lohmann
Oct 30, 2012·Nature Neuroscience·Polyxeni PhilippidouJeremy S Dasen
Oct 8, 2013·Neuron·Polyxeni Philippidou, Jeremy S Dasen

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Citations

Mar 20, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rebecca G SmithKatie Lunnon
Sep 2, 2016·Journal of Developmental Biology·Arya Zandvakili, Brian Gebelein
Apr 26, 2018·Current Opinion in Neurobiology·Clinton Cave, Shanthini Sockanathan
Mar 21, 2021·Insect Biochemistry and Molecular Biology·Sihan HouChun Liu
Sep 4, 2019·Developmental Biology·Catarina Catela, Paschalis Kratsios
Aug 24, 2021·Frontiers in Cell and Developmental Biology·James C-G HombríaCarlos Sánchez-Higueras

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