HOX genes function in Breast Cancer development

Biochimica Et Biophysica Acta. Reviews on Cancer
Simone Aparecida de Bessa GarciaRenata Freitas

Abstract

Breast cancer develops in the mammary glands during mammalian adulthood and is considered the second most common type of human carcinoma and the most incident and mortal in the female population. In contrast to other human structures, the female mammary glands continue to develop after birth, undergoing various modifications during pregnancy, lactation and involution under the regulation of hormones and transcription factors, including those encoded by the HOX clusters (A, B, C, and D). Interestingly, HOX gene deregulation is often associated to breast cancer development. Within the HOXB cluster, 8 out of the 10 genes present altered expression levels in breast cancer with an impact in its aggressiveness and resistance to hormone therapy, which highlights the importance of HOXB genes as potential therapeutic targets used to overcome the limitations of tamoxifen-resistant cancer treatments. Here, we review the current state of knowledge on the role of HOX genes in breast cancer, specially focus on HOXB, discussing the causes and consequences of HOXB gene deregulation and their relevance as prognostic factors and therapeutic targets.

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Citations

Oct 21, 2020·Scientific Reports·Sebastian Carrasco ProJuan Ignacio Fuxman Bass
Dec 31, 2020·Cancers·Ana PaçoRenata Freitas
Jun 3, 2021·Biomedicines·Simone Aparecida de Bessa GarciaRenata Freitas
Jun 2, 2021·Gene·Ajay KumarAnil Mukund Limaye
Jun 12, 2021·Frontiers in Oncology·Jinyong FangWenxia Xu
Jul 25, 2021·International Journal of Molecular Sciences·María J PajaresJuan Sandoval
Jul 24, 2021·Experimental Biology and Medicine·Dan GongJianwu Ding
Aug 10, 2021·Biochemistry and Biophysics Reports·Waseem El-HuneidiJibran Sualeh Muhammad
Sep 8, 2021·Frontiers in Oncology·Magali BelpaireRené Rezsohazy
Oct 5, 2021·Journal of Clinical Laboratory Analysis·Fenfen GeYingying Fan
Nov 10, 2021·Future Oncology·Mei-Qian WangSen-Lin Zhu

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