HOX Genes in High Grade Ovarian Cancer

Cancers
Praveena IdaikkadarAgnieszka Michael

Abstract

HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. High grade ovarian cancer is the most lethal gynaecological malignancy. Our understanding of the role of HOX genes in the oncogenesis of ovarian cancer is evolving, and here we review their dysregulated expression patterns, their function in cell survival and invasion, their potential uses as biomarkers, and ways in which HOX genes are being targeted with new and existing drugs.

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Citations

May 28, 2020·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Danielle Barbosa BrottoWilson Araújo da Silva
Mar 10, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Simone Aparecida de Bessa GarciaRenata Freitas

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Methods Mentioned

BETA
xenografts
hysterectomy

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