PMID: 9443054Jan 27, 1998Paper

Hox homeobox genes as regulators of normal and leukemic hematopoiesis

Hematology/oncology Clinics of North America
U ThorsteinsdottirR Keith Humphries

Abstract

Hox genes, first recognized for their role in embryonic development, may also play lineage-specific functions in a variety of somatic tissues including the hematopoietic system. Expression of these transcription factors has been demonstrated both in normal and leukemic human and hematopoietic cells, suggesting functional roles in hematopoietic cell growth and differentiation. Several recent studies have shown that Hox proteins are involved in controlling proliferation of primitive bone marrow cells and also in altering differentiation of myeloid as well as lymphoid progenitors, alterations that also can contribute to leukemic transformation. Hox genes, together with their upstream regulators and downstream target genes, may play key roles in fundamental processes controlling hematopoietic stem cell properties.

References

Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Mar 31, 1992·Biochemical and Biophysical Research Communications·I Vieille-GrosjeanG Courtois
Dec 1, 1991·Molecular and Cellular Biology·K MonicaM L Cleary
Oct 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S J Gaunt
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M C MagliE Boncinelli
Dec 26, 1991·Annals of the New York Academy of Sciences·C J BieberichK S Stenn
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D LavelleJ DeSimone
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A PerkinsS Cory
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W F ShenH J Lawrence
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M P Scott, A J Weiner
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·G SauvageauR K Humphries
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·A CelettiM C Magli
Mar 3, 1995·The Journal of Biological Chemistry·I Vieille-Grosjean, P Huber
Mar 10, 1995·The Journal of Biological Chemistry·S H Orkin

❮ Previous
Next ❯

Citations

May 16, 2001·Arthritis and Rheumatism·N D KhoaK Nishioka
Jan 22, 2004·Archives of Medical Research·Kristin J HopeJohn E Dick
Jun 27, 2000·Leukemia Research·R A SteinmanD S Shields
Oct 17, 2001·Developmental and Comparative Immunology·D R Barreda, M Belosevic
Jul 5, 2003·Experimental Hematology·Julie Lessard, Guy Sauvageau
Dec 12, 2001·Trends in Immunology·F M RaaphorstC J Meijer
Oct 3, 2002·British Journal of Haematology·Toshihiko ImamuraShinsaku Imashuku
Aug 11, 2007·DNA and Cell Biology·Yasmin GosiengfiaoAlexis Thompson
Dec 29, 2005·Lymphatic Research and Biology·Kim RhoadsNancy Boudreau
Feb 6, 2004·Current Opinion in Pediatrics·Amy E Geddis, Kenneth Kaushansky
Dec 13, 2000·Molecular and Cellular Biology·U ThorsteinsdottirG Sauvageau
May 16, 2003·Molecular and Cellular Biology·Jon Mar BjörnssonStefan Karlsson
Sep 20, 2012·Blood·Constanze BreitingerRobert K Slany
Sep 14, 2004·Leukemia & Lymphoma·Christopher Slape, Peter D Aplan
May 18, 2001·Best Practice & Research. Clinical Haematology·A Dash, D G Gilliland
Nov 18, 2005·Biochemical and Biophysical Research Communications·Donald G PhinneyAmitabh Pandey
May 9, 2001·Leukemia & Lymphoma·T D AllenR G Hawley
Feb 7, 2006·Experimental Hematology·Hui Z ZhangBernard G Forget
Apr 1, 2004·American Journal of Medical Genetics. Part a·Nicola Brunetti-PierriBrendan Lee
Oct 30, 2001·Leukemia·D H Lam, P D Aplan
Sep 21, 2004·Oncogene·Jennifer K WarnerJohn E Dick
Apr 2, 2010·Nature Reviews. Cancer·Nilay Shah, Saraswati Sukumar
May 29, 2002·Oncogene·Jiang Zhu, Stephen G Emerson
May 29, 2002·Oncogene·Richard A Steinman
Nov 4, 2000·Nature Medicine·M Brenner
Sep 22, 2006·Human Molecular Genetics·Aleksandra RizoJan Jacob Schuringa
Jan 1, 1998·Journal of Cellular Biochemistry·Vaskar SahaPaul S Freemont
Oct 31, 2015·Journal of Experimental & Clinical Cancer Research : CR·Xiupeng LvLei Dong
Nov 20, 2019·Genes·Kallayanee Chawengsaksophak
Jun 21, 2005·Experimental Hematology·Malcolm A S Moore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.