HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium

The Journal of Clinical Investigation
Hugh S TaylorP Igarashi

Abstract

Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit uterine factor infertility. We have recently demonstrated that HOXA10 is expressed in the adult human uterus. To examine expression of HOXA10 during the menstrual cycle, Northern blot analysis and in situ hybridization were performed. Expression of HOXA10 dramatically increased during the midsecretory phase of the menstrual cycle, corresponding to the time of implantation and increase in circulating progesterone. Expression of HOXA10 in cultured endometrial cells was stimulated by estrogen or progesterone. Stimulation of HOXA10 by progesterone was concentration-dependent within the physiologic range, and the effect of estrogen was inhibited by cycloheximide. These results identify sex steroids as novel regulators of HOX gene expression. HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human.

References

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Citations

Feb 7, 2012·EMBO Molecular Medicine·Olga GrechukhinaHugh S Taylor
Feb 14, 2009·Journal of Assisted Reproduction and Genetics·Lora K ShahineRuth B Lathi
Sep 8, 2010·Journal of Assisted Reproduction and Genetics·Alysson ZanattaPaulo C Serafini
Oct 16, 2003·Placenta·P ViganòI Chiodo
Oct 16, 2003·Placenta·M Cavagna, J C Mantese
Feb 7, 2009·Seminars in Reproductive Medicine·Ozlem Guzeloglu-KayisliHugh S Taylor
Jan 28, 2010·Seminars in Reproductive Medicine·Cyril Y RamathalMilan K Bagchi
Jan 28, 2010·Seminars in Reproductive Medicine·Hakan Cakmak, Hugh S Taylor
Aug 24, 2010·Human Reproduction Update·Hakan Cakmak, Hugh S Taylor
May 14, 2010·Biology of Reproduction·Hongling DuHugh S Taylor
Feb 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason G BromerHugh S Taylor
May 9, 2009·Menopause : the Journal of the North American Menopause Society·Kathleen A ConnellHugh S Taylor
Jun 11, 2010·Proceedings. Biological Sciences·Wolfgang ForstmeierBart Kempenaers
Dec 17, 2002·Molecular and Cellular Biology·Patrick J TroyHugh S Taylor
Oct 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Leo F DohertyHugh S Taylor
Jan 28, 2010·American Journal of Physiology. Endocrinology and Metabolism·Homayoun Sadeghi, Hugh S Taylor
Sep 17, 2004·The Journal of Clinical Investigation·Kristy Red-HorseSusan J Fisher
Feb 16, 2008·The Journal of Clinical Investigation·Kathleen A ConnellHugh S Taylor
Sep 5, 2012·The Journal of Clinical Investigation·Song Yi KoHonami Naora
Feb 12, 2009·Reproductive Sciences·Gerson WeissHugh S Taylor
Apr 18, 2009·Reproductive Sciences·Kathleen A ConnellHugh S Taylor
Jan 12, 2012·Reproductive Biology and Endocrinology : RB&E·Malgorzata SzczepańskaPaweł P Jagodziński
Nov 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Donna C SinclairHugh S Taylor
Oct 1, 2011·The Journal of Clinical Endocrinology and Metabolism·Rafaella PetraccoHugh S Taylor
May 1, 2004·The Journal of Reproduction and Development·Kazuhiko ImakawaRonald K Christenson
Aug 4, 2011·Environmental Health Perspectives·Wendy N JeffersonCarmen J Williams
Sep 26, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Hongling DuHugh S Taylor

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