HOXA5 and p53 cooperate to suppress lung cancer cell invasion and serve as good prognostic factors in non-small cell lung cancer

Journal of Cancer
Chi-Jen ChangChi-Chung Wang

Abstract

Lung cancer is the leading cause of cancer mortality worldwide and tumor metastasis is the major cause of cancer-related death. Our previous study suggested that Homeobox A5 (HOXA5) could inhibit lung cancer cell invasion via regulating cytoskeletal remodeling and involved in tumor metastasis. Recently, consensus HOX binding sites was found in the p53 gene promoter region. However, whether the HOXA5 could cooperate with p53 and contribute the inhibition of lung cancer cell invasion is still unclear. The aim of the current study is to elucidate the correlation of HOXA5 and p53 in tumor invasion and its prognostic influence in lung cancer patient specimens. Totally 71 cases of primary non-small cell lung cancer (NSCLC) were collected. The median follow-up period is 6.8 years. Immunohistochemical stain for p53 and HOXA5 were performed. Kaplan-Meier plot was done for overall survival analysis. In addition, lung cancer cell lines transfected with wild-type or mutated p53 constructs were overexpressed with HOXA5 for invasion assay. In human specimens, HOXA5 expressed mainly in the cytoplasm (54.1%) rather than nuclei (14.6%) of the NSCLC tumor part. The HOXA5 expression is higher in adenocarcinoma than in squamous cell carcinoma (P <...Continue Reading

Citations

Jul 20, 2018·EMBO Reports·Luis Filipe Costa-MachadoPablo J Fernandez-Marcos
Oct 2, 2019·Current Molecular Medicine·Parisa NaeliHamed Mirzaei
Jun 24, 2020·Cancer Metastasis Reviews·Joy JonkersSaraswati Sukumar
Jul 18, 2020·Cancer Biomarkers : Section a of Disease Markers·Xiaoli WangFang Zhang
Jul 3, 2021·International Journal of Molecular Sciences·Sadaf DorandishHedeel Guy Evans

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
zymography

Software Mentioned

SPSS
Kaplan Meier - plotter

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.