PMID: 9450632Feb 5, 1998Paper

Hoxb-5 expression in the developing mouse lung suggests a role in branching morphogenesis and epithelial cell fate

Histochemistry and Cell Biology
MaryAnn V VolpeHeber C Nielsen

Abstract

Hoxb-5 is one of the few homeobox genes strongly expressed in the developing mouse lung. To explore the hypothesis that Hoxb-5 acts to regulate epithelial cell fate and branching morphogenesis in the developing lung, we studied the temporal, spatial, and cell-specific expression of Hoxb-5 from gestational day (d) 13.5 to postnatal day (P) 2. Immunocytochemistry demonstrated regional localization of Hoxb-5 protein to developing conducting airways and surrounding mesenchyme. The cellular expression pattern changed from diffusely positive nuclei of mesenchymal cells on d13.5 to become more localized to nuclei of subepithelial fibroblasts and some adjacent columnar and cuboidal epithelial cells on d14.5. After d14.5, Hoxb-5 protein expression continued to decrease in mesenchymal cells distal from developing airways, but persisted in fibroblasts underlying conducting airways. Hoxb-5 protein expression persisted in nuclei of columnar and cuboidal epithelial cells on d16.5 and d17.5, with expression in low cuboidal epithelial cells as well from d17.5 to P2. Western blot analysis showed temporal and quantitative changes in Hoxb-5 protein expression with peak expression on d14.5-15.5. We conclude that Hoxb-5 protein is developmentally r...Continue Reading

Citations

Nov 5, 2003·Trends in Cardiovascular Medicine·Peter Lloyd Jones
Oct 22, 2003·Molecular Genetics and Metabolism·MaryAnn V VolpeMala R Chinoy
Mar 8, 2000·Mechanisms of Development·D WarburtonW V Cardoso
Nov 18, 1998·Current Opinion in Cell Biology·N Boudreau, M J Bissell
Jun 28, 2014·Journal of Developmental Origins of Health and Disease·M E ProbynK M Moritz
May 5, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Maryann V VolpeHeber C Nielsen
Apr 19, 2008·American Journal of Respiratory Cell and Molecular Biology·Sílvia GonzagaAlan W Flake
Feb 15, 2013·PloS One·Sana MujahidMaryAnn V Volpe
Jul 31, 2014·Journal of Cell Communication and Signaling·Francheyska Silfa-MazaraMaryAnn V Volpe
Jan 23, 2016·International Journal of Molecular Sciences·Khondoker M AkramNicholas R Forsyth
Oct 1, 2013·BioMed Research International·MaryAnn V VolpeHeber C Nielsen
Jun 17, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·MaryAnn Vitoria VolpeMala Romeshchandra Chinoy
Mar 2, 2013·Journal of Anatomy·Tatsuya Hirasawa, Shigeru Kuratani
Jan 12, 2012·Fetal and Pediatric Pathology·Wei XuXindong Xue
Sep 11, 2007·American Journal of Obstetrics and Gynecology·Xiangyuan WangLaxmi Baxi
Jun 30, 2006·Developmental Biology·Zengxin WangKaren Niederreither
Mar 10, 2001·The American Journal of Pathology·H A GolponN F Voelkel
Sep 7, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Wolfram F J RiedlingerHarry P W Kozakewich
Feb 19, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A I PackerD J Wolgemuth
Sep 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C W BogueH C Jacobs
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N OhtsukaH Nogawa
Jan 14, 2011·Fetal Diagnosis and Therapy·Xiangyuan WangLaxmi V Baxi
Nov 25, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·MaryAnn V VolpeHeber C Nielsen
Apr 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·T Bernard Kinane
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C HagiosM J Bissell
Mar 25, 2011·Biochemical Society Transactions·Hong-Xing WangMartin E Hemler
Feb 11, 1999·The Journal of Cell Biology·M Vivinus-NebotA Bernard
Aug 12, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J C JonesL E Goldfinger
Feb 14, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruoxi HuQuan Lu
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R H CostaL Lim
Feb 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kwanchai ArchavachotikulMaryann V Volpe
Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·C Kim, H C Nielsen
May 12, 1998·The American Journal of Physiology·M R ChinoyT M Krummel
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Kirk A. Gilbert, D. Eugene Rannels
Oct 12, 1999·The American Journal of Physiology·A PavlovaS K Nigam
Apr 15, 2006·Development·Wellington V Cardoso, Jining Lü

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.