PMID: 7547473Jun 1, 1995Paper

Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs

Mechanisms of Development
H SuemoriS Noguchi

Abstract

To clarify the function of the Hoxc-9 gene, we have introduced a mutation into the Hoxc-9 locus by gene targeting. Skeletal analysis of homozygotes revealed that anterior homeotic transformation occurred from the 10th thoracic vertebrae to the first lumbar vertebra. Bending and fusion of the ribs were observed. Eight or nine pairs of ribs were attached to the sternum. The sternum showed an abnormal pattern of ossification. Phenotypes of the mutant mice resembled those of the Hoxc-8 mutant mice. The data suggested that a functional interaction between the Hoxc-8 and Hoxc-9 proteins is involved in segmental determination. Moreover, changes in the Hoxc-8 gene expression pattern suggested that the Hoxc-9 gene regulates expression of the Hoxc-8 gene.

References

Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C J BieberichF H Ruddle
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P L SchwartzbergS P Goff
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T YagiS Aizawa
Jan 1, 1988·Genes & Development·H Le MouellicP Brûlet
Nov 1, 1993·Genes & Development·L JeannotteE J Robertson
Dec 1, 1993·Genes & Development·K M Small, S S Potter
May 1, 1993·Molecular & General Genetics : MGG·J GotoM Muramatsu

❮ Previous
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Citations

May 15, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T SekimotoK Yamamura
Jun 26, 2001·Development, Growth & Differentiation·M TsukaharaH Tsunoo
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H G BeltingF H Ruddle
Mar 1, 1996·Environmental Health Perspectives·R J Kavlock, R W Setzer
Jul 31, 2012·Trends in Cardiovascular Medicine·Sandra Jasmin Stoll, Jens Kroll
Oct 17, 2014·Zygote : the Biology of Gametes and Early Embryos·Wataru YamazakiManabu Kawahara
Nov 10, 2011·American Journal of Medical Genetics. Part a·Nobuhiko OkamotoToshiyuki Yamamoto
Jul 24, 2012·Developmental Biology·Huang ZhuXizhi Guo
Feb 19, 2002·Mechanisms of Development·M Todd ValeriusS Steven Potter
Feb 15, 2003·Developmental Cell·A C Burke, J L Nowicki
Nov 19, 2013·Molecular Genetics and Metabolism·Shane C Quinonez, Jeffrey W Innis
Apr 22, 2016·American Journal of Physical Anthropology·Allison L MachnickiPhilip L Reno
Sep 10, 2002·Developmental Biology·Anne M Boulet, Mario R Capecchi
Dec 18, 2001·Mechanisms of Development·M Todd ValeriusS Steven Potter
Jun 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J ShangD A Clayton
Jun 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S KurataniS Aizawa
Jan 28, 2003·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Michael Crawford
Aug 10, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Deneen M Wellik
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·C KappenR Finnell
May 19, 2016·The Journal of Craniofacial Surgery·MeiRong YangBo Pan
Feb 23, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Andrea D WestonNigel A Brown
May 11, 2020·Journal of Human Evolution·Allison L Machnicki, Philip L Reno
Nov 21, 2019·Cell Reports·Eamon CoughlanEdwina McGlinn
Jul 30, 1999·Biochemical and Biophysical Research Communications·T MasakiS Noguchi
Mar 1, 1996·Mechanisms of Development·S SteinM Kessel
Jun 12, 2021·Frontiers in Oncology·Jinyong FangWenxia Xu

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