HOXC10 promotes gastric cancer cell invasion and migration via regulation of the NF-κB pathway

Biochemical and Biophysical Research Communications
Sheng YaoSenlin Zhu

Abstract

Homeobox gene C10 (HOXC10), known to regulate cell differentiation and proliferation, is upregulated in gastric cancer (GC). The mechanism underlying HOXC10 involvement in GC metastasis is unclear. Herein, we found that HOXC10 is overexpressed in GC relative to normal controls. In the 73 GC patients tissue microarrays (TMA) tested, HOXC10 expression was closely related with tumor-node-metastasis (TNM) stage, lymph node metastasis, and distant metastasis. HOXC10 overexpression tended to associate with low 5-year cumulative survival. Cox regression analysis identified HOXC10 as an independent prognostic factor for poor patient survival. HOXC10 promoted GC cell invasion and migration, regulated the expression of activated ATM and markers of NF-κB signaling. HOXC10 may promote invasion and migration of GC by regulating ATM/NF-κB signaling pathway. HOXC10 should be explored as a clinical marker of GC prognosis.

Citations

May 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiamin HeShujie Chen
Mar 17, 2020·Cancer Biomarkers : Section a of Disease Markers·Tao FuJiafu Ji
Jun 12, 2021·Frontiers in Oncology·Jinyong FangWenxia Xu
Oct 8, 2021·Cell Biology and Toxicology·U Sangeetha ShenoyRaghu Radhakrishnan

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