HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy

PloS One
Young-Ho LeeDavid K Ann

Abstract

Members of the heterochromatin protein 1 family (HP1α, β and γ) are mostly associated with heterochromatin and play important roles in gene regulation and DNA damage response. Altered expression of individual HP1 subtype has profound impacts on cell proliferation and tumorigenesis. We analyzed the expression profile of HP1 family by data mining using a published microarray data set coupled with retrospective immunohistochemistry analyses of archived breast cancer biospecimens. We found that the patient group overexpressing HP1β mRNA is associated with poorly differentiated breast tumors and with a significantly lower survival rate. Immunohistochemical staining against HP1α, HP1β and HP1γ shows that respective HP1 expression level is frequently altered in breast cancers. 57.4-60.1% of samples examined showed high HP1β expression and 39.9-42.6 % of examined tumors showed no or low expression of each HP1 subtype. Interestingly, comparative analysis on HP1 expression profile and breast cancer markers revealed a positive correlation between the respective expression level of all three HP1 subtypes and Ki-67, a cell proliferation and well-known breast cancer marker. To explore the effect of individual HP1 on PARP inhibitor therapy fo...Continue Reading

References

Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Apr 8, 2000·Current Opinion in Genetics & Development·J C Eissenberg, S C Elgin
Aug 30, 2000·Nature·C M PerouD Botstein
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Dec 18, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ai KametakaYoshihiro Yoneda
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
May 16, 2003·Lancet·Erich HuangAndrew T Huang
Oct 29, 2004·Nature Reviews. Cancer·Nicholas TurnerAlan Ashworth
Feb 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Howard Y ChangMarc J van de Vijver
Aug 2, 2005·Nature Reviews. Cancer·Britta WeigeltLaura J van 't Veer
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ander UrruticoecheaMitch Dowsett
Nov 2, 2005·Cellular and Molecular Life Sciences : CMLS·K Hiragami, R Festenstein
Oct 18, 2008·Mutation Research·George K DialynasLori L Wallrath
May 20, 2009·The Journal of Cell Biology·Alexander R Ball, Kyoko Yokomori
Jun 26, 2009·The New England Journal of Medicine·Peter C FongJohann S de Bono
Oct 7, 2009·Molecular and Cellular Biology·Christoffel Dinant, Martijn S Luijsterburg
Jan 6, 2010·EMBO Molecular Medicine·Leanne De KoningGeneviève Almouzni
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert C Bast, Gordon B Mills
Feb 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W Jonat, N Arnold
Apr 5, 2011·Breast Cancer Research : BCR·Barbara Adamo, Carey K Anders
Apr 14, 2011·Cell Cycle·Konstantin J DedesJorge S Reis-Filho
Jan 19, 2012·PloS One·Weiya Z WyshamTanja Pejovic
Jun 8, 2012·The Oncologist·Georgios Rigakos, Evangelia Razis
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jan 17, 2013·Translational Oncology·Enrique Espinosa ArranzPilar Zamora
Apr 17, 2013·Nucleic Acids Research·Young-Ho LeeDavid K Ann
Jul 25, 2013·The Oncologist·Pavani Chalasani, Robert Livingston

❮ Previous
Next ❯

Citations

Jun 22, 2016·Current Molecular Biology Reports·Gunes UzerJanet Rubin
Dec 23, 2017·Expert Review of Proteomics·Claudius MuellerVirginia Espina
Dec 2, 2017·Oncotarget·Yuan-Ke LiangDe Zeng
Jan 4, 2019·Interdisciplinary Sciences, Computational Life Sciences·Bo HuXiaoping Liu
Jun 13, 2021·Scientific Reports·Mengya HeRongguang Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
light microscopy
flow cytometry

Software Mentioned

MS
SAS
JMP
Access
BRAVO
GraphPad Prism

Related Concepts

Related Feeds

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.