HPA-axis reactivity interacts with stage of pubertal development to predict the onset of depression

Psychoneuroendocrinology
Natalie L ColichIan H Gotlib

Abstract

Both elevated and blunted levels of cortisol secretion during childhood and adolescence have been linked to the subsequent onset of major depressive disorder (MDD). These mixed findings may be due to developmental changes in HPA-axis functioning, which have not been previously assessed in the context of risk. In the present study, therefore, we examined whether pubertal development moderated the influence of cortisol secretion on the subsequent development of MDD. Eighty-nine never-disordered girls ages 9-15 years, many of whom were at high risk for depression by virtue of having a maternal history of the disorder, completed a laboratory stress task. To index cortisol reactivity, salivary cortisol samples were collected at baseline and 15 min following the onset of the stressor. Girls' levels of pubertal development were measured using Tanner staging. All participants were followed through age 18 in order to assess the subsequent development of MDD. Pubertal stage moderated the effects of cortisol stress reactivity on the development of MDD. Specifically, the onset of MDD was predicted by cortisol hyporeactivity in girls who were earlier in pubertal development (Tanner stage ≤ 2), but by cortisol hyperreactivity in girls who we...Continue Reading

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Citations

Jan 9, 2016·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Bonnie Klimes-Dougan, Judy Garber
Dec 15, 2015·Acta Paediatrica·Eva Henje BlomTony T Yang
Nov 5, 2015·Development and Psychopathology·Audrey R TyrkaRonald Seifer
Jun 3, 2017·Social Cognitive and Affective Neuroscience·Natalie L ColichIan H Gotlib
Jul 18, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Kalsea J Koss, Megan R Gunnar
Mar 15, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Lorah D DornPanagiota Pervanidou
Mar 15, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Lisa J CrockettAnne C Petersen
Sep 21, 2017·Development and Psychopathology·Stephanie StadelmannMirko Döhnert
May 9, 2019·Development and Psychopathology·Katharina KircanskiIan H Gotlib
Jun 5, 2020·Nordic Journal of Psychiatry·Serkan KaradenizSerap Özer Yaman
Dec 21, 2017·Stress : the International Journal on the Biology of Stress·Meghan E QuinnEmma K Adam
Nov 21, 2019·Molecular Psychiatry·Mitzy KennisClaudi Bockting
Apr 8, 2020·Adolescent Research Review·Orianna DuncanAmber Champagne
Feb 20, 2017·Journal of Abnormal Child Psychology·Kate R KuhlmanNestor Lopez-Duran
Jan 22, 2020·Annual Review of Clinical Psychology·Sherryl H Goodman
Jan 2, 2021·NeuroImage. Clinical·Rachel CorrAysenil Belger
Jan 2, 2021·Biological Psychiatry·Angélica Torres-BerríoCecilia Flores
Mar 25, 2021·Current Directions in Psychological Science·Ian H GotlibKathryn L Humphreys
Sep 17, 2021·Child Psychiatry and Human Development·Allison Stumper, Lauren B Alloy

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