HPLC identification of oversulphated chondroitin as the major glycosaminoglycan of human tonsils

Biomedical Chromatography : BMC
I E TriantaphyllidouD H Vynios

Abstract

The glycosaminoglycans of human nasopharyngeal and palatine tonsils, obtained after surgical dissection due to tonsillitis, were isolated and characterized by means of enzyme susceptibility and HPLC. Chondroitin/dermatan sulphate were the major glycosaminoglycans identified. A large proportion of this glycosaminoglycan was made up of oversulphated structures, namely DeltaDi-di(4,6)S, which were found mainly in invertebrate tissues and in mast cells.

References

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