HPMA copolymers: origins, early developments, present, and future.

Advanced Drug Delivery Reviews
Jindřich Kopeček, Pavla Kopecková

Abstract

The overview covers the discovery of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, initial studies on their synthesis, evaluation of biological properties, and explorations of their potential as carriers of biologically active compounds in general and anticancer drugs in particular. The focus is on the research in the authors' laboratory - the development of macromolecular therapeutics for the treatment of cancer and musculoskeletal diseases. In addition, the evaluation of HPMA (co)polymers as building blocks of modified and new biomaterials is presented: the utilization of semitelechelic poly(HPMA) and HPMA copolymers for the modification of biomaterial and protein surfaces and the design of hybrid block and graft HPMA copolymers that self-assemble into smart hydrogels. Finally, suggestions for the design of second-generation macromolecular therapeutics are portrayed.

Citations

Dec 10, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Acharaporn DuangjaiJindřich Kopeček
Sep 13, 2011·Biomacromolecules·Fuxing ZhanZhiyuan Zhong
Oct 26, 2011·Biomacromolecules·Kelly M SchultzEric M Furst
Feb 1, 2012·Biomacromolecules·Russell N JohnsonJindřich Kopeček
Mar 30, 2012·Biomacromolecules·Maarten DanialHarm-Anton Klok
Oct 3, 2013·Biomacromolecules·Sergey K FilippovDmitri I Svergun
Jun 19, 2012·Chemistry of Materials : a Publication of the American Chemical Society·Nate Larson, Hamidreza Ghandehari
Aug 3, 2010·Molecular Pharmaceutics·Jindrich Kopecek
Sep 9, 2011·Nanoscale·Ruben Huis In 't VeldTwan Lammers
May 24, 2012·Journal of Drug Delivery·Jun H Lee, Anjan Nan
Oct 26, 2013·Journal of Biological Engineering·Julie ShiSuzie H Pun
Jul 26, 2013·Therapeutic Delivery·Alicia Sawdon, Ching-An Peng
Nov 15, 2012·Nanomedicine·Julia Y Ljubimova, Eggehard Holler
May 16, 2014·Nanomedicine·Jindřich Kopeček, Hannah Stanwix
Mar 19, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Benjamin TheekTwan Lammers
Jan 22, 2013·Annual Review of Physical Chemistry·Jessica Y ShuTing Xu
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rui ZhangJindřich Kopeček
Oct 29, 2013·Journal of Drug Targeting·Xiang Yi, Alexander V Kabanov
Oct 8, 2011·Journal of Drug Targeting·T EtrychK Ulbrich
Aug 23, 2011·Expert Opinion on Drug Delivery·Chen ChenMahendra Deonarain
Sep 27, 2012·Journal of Drug Targeting·Yan Zhou, Jindřich Kopeček
Nov 16, 2011·Journal of Drug Targeting·Adam J GormleyHamidreza Ghandehari
Dec 15, 2010·Expert Opinion on Drug Delivery·Franco DosioLuigi Cattel
Jan 22, 2011·Expert Opinion on Drug Delivery·Andrew Gregory, Martina H Stenzel

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