HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results

AIDS and Behavior
Audrey PettiforHPTN 068 protocol team

Abstract

Young women in South Africa are at high risk for HIV infection. Cash transfers offer promise to reduce HIV risk. We present the design and baseline results from HPTN 068, a phase III, individually randomized trial to assess the effect of a conditional cash transfer on HIV acquisition among South African young women. A total of 2533 young women were randomized to receive a monthly cash transfer conditional on school attendance or to a control group. A number of individual-, partner-, household- and school-level factors were associated with HIV and HSV-2 infection. After adjusting for age, all levels were associated with an increased odds of HIV infection with partner-level factors conveying the strongest association (aOR 3.05 95 % CI 1.84-5.06). Interventions like cash transfers that address structural factors such as schooling and poverty have the potential to reduce HIV risk in young women in South Africa.

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Citations

Dec 24, 2017·AIDS and Behavior·Brittany S IskarpatyotiMahua Mandal
Apr 19, 2016·Journal of the International AIDS Society·Lucie Dale CluverLorraine Sherr
Jul 30, 2016·Journal of the International AIDS Society·Meghna RanganathanCharlotte Watts
Dec 30, 2017·Journal of the International AIDS Society·Elizabeth FearonJames R Hargreaves
Jul 6, 2018·PloS One·Mariya V SivayMary Kathryn Grabowski
Jul 10, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yinfeng ZhangSusan H Eshleman
Mar 2, 2019·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Marie C D StonerAudrey Pettifor
Nov 9, 2016·The Cochrane Database of Systematic Reviews·Amanda J Mason-JonesCarl Lombard
Mar 8, 2019·Journal of Epidemiology and Community Health·Melissa CortinaMina Fazel
Jul 30, 2019·Journal of the International AIDS Society·Danielle GiovencoJames P Hughes
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Meghna RanganathanAudrey Pettifor
Jun 27, 2017·The Pediatric Infectious Disease Journal·Allison R KirkpatrickOliver Laeyendecker
Jan 7, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hillary M TopazianAudrey Pettifor
May 4, 2016·Current HIV/AIDS Reports·Lyle R McKinnon, Quarraisha Abdool Karim
Jun 10, 2020·Bulletin of the World Health Organization·Charlotte JamesKatharine J Looker
Feb 28, 2018·Journal of the International AIDS Society·Hayley S GleesonDoortje't Hart
Sep 14, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marie C D StonerAudrey Pettifor
Dec 14, 2018·HIV Clinical Trials·Mariya V SivaySusan H Eshleman
Feb 24, 2018·African Journal of AIDS Research : AJAR·Rebecca Hodes, Robert Morrell
Dec 8, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Molly S RosenbergTill Bärnighausen

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