Aug 26, 2016

HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

Infectious Agents and Cancer
Bianca Rivera-PeñaAdriana Báez


HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x(2). Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.

  • References37
  • Citations2


Mentioned in this Paper

Viral Oncogene
Entire Oral Cavity
Human Papillomavirus
TNM Staging System
APH1A protein, human
E2 protein, Human papillomavirus type 16
Benign Neoplasm of Larynx
Imaging Guided Therapy
Laryngeal Diseases

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