HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer

FEBS Letters
Sen WangXinrong Hu

Abstract

Increasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over-expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over-expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. Therefore, eIF4E emerges as a key player in tumor development and progression and a potential target for CC treatment and prevention.

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Citations

Aug 21, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chunxia RenGong Yang
Jul 6, 2016·Pharmacological Reports : PR·Sapna SharmaMilee Agarwal
Jul 15, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tianyun PangXinrong Hu
Dec 11, 2019·International Journal of Molecular Sciences·Maria Anna SmolleJohannes Haybaeck
Aug 13, 2020·Cancers·Francisco AguayoDaniela Nuñez-Acurio
Sep 28, 2020·FEBS Open Bio·Vicente Morales-GarciaErick de la Cruz-Hernandez
Nov 6, 2020·Cell Communication and Signaling : CCS·Peiqi HaoTianrui Xu
Oct 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alejandra GarcíaGreco Hernández

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