HPV entry into cells

Mutation Research. Reviews in Mutation Research
Pinar AksoyPatricio I Meneses

Abstract

Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 15 additional cancer-causing HPVs have been identified that the vaccines do not protect against. Therefore, roughly 150,000 cancer cases will not be prevented annually with the current vaccines. Research efforts focused on the basic cell biology of HPV infection have a goal of identifying common infectious events that may lead to inexpensive vaccines or anti-virals to prevent infection by most, if not all, HPVs. In this review we attempt to summarize what is known regarding the process of HPV binding, entry, and intracellular trafficking.

Citations

Dec 1, 2017·Journal of Clinical Medicine·Uyen Ngoc MuiStephen K Tyring
Sep 5, 2018·European Journal of Oral Sciences·Stina Syrjänen
Apr 19, 2019·Journal of Virology·Justyna BroniarczykLawrence Banks
Feb 29, 2020·Journal of Medical Virology·Abdo A Elfiky
Aug 1, 2019·International Journal of Oncology·Yu LiuXiaorong Qi
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Jul 11, 2019·Oncology Letters·Jorge Organista-NavaBerenice Illades-Aguiar
Jan 12, 2021·The Journal of General Virology·James A ScarthAndrew Macdonald
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