Abstract
Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 15 additional cancer-causing HPVs have been identified that the vaccines do not protect against. Therefore, roughly 150,000 cancer cases will not be prevented annually with the current vaccines. Research efforts focused on the basic cell biology of HPV infection have a goal of identifying common infectious events that may lead to inexpensive vaccines or anti-virals to prevent infection by most, if not all, HPVs. In this review we attempt to summarize what is known regarding the process of HPV binding, entry, and intracellular trafficking.
Citations
Dec 1, 2017·Journal of Clinical Medicine·Uyen Ngoc MuiStephen K Tyring
Dec 7, 2017·Viruses·Samuel K Campos
Sep 5, 2018·European Journal of Oral Sciences·Stina Syrjänen
Jan 18, 2018·Scientific Reports·Justyna BroniarczykLawrence Banks
Apr 19, 2019·Journal of Virology·Justyna BroniarczykLawrence Banks
May 1, 2019·Acta Oto-laryngologica·Chouard Claude-HenriJean-François Sadoc
Feb 29, 2020·Journal of Medical Virology·Abdo A Elfiky
Apr 29, 2020·IUBMB Life·Iraj MohammadzadehMostafa Vaghari-Tabari
Aug 5, 2018·Scientific Reports·Julia R TaylorW Martin Kast
Nov 8, 2018·Marine Drugs·Gabriella DonàLuciana Bordin
Aug 1, 2019·International Journal of Oncology·Yu LiuXiaorong Qi
Apr 25, 2019·Viruses·Elizabeth A White
Oct 16, 2019·Frontiers in Microbiology·Chen HuaShibo Jiang
Mar 29, 2020·Frontiers in Oncology·Sayuri Itzel Clemente-PerivánBerenice Illades-Aguiar
Sep 25, 2020·Scientific Reports·Timra D GilsonElliot J Androphy
Jul 11, 2019·Oncology Letters·Jorge Organista-NavaBerenice Illades-Aguiar
Jan 12, 2021·The Journal of General Virology·James A ScarthAndrew Macdonald
Feb 17, 2021·Reviews in Medical Virology·Ana Karina Aranda-RiveraJosé Pedraza-Chaverri
Apr 24, 2021·Biomaterials Science·Ya-Rong XueYuqing Wu
Mar 19, 2021·Journal of Virology·Marina Bugnon ValdanoLawrence Banks
Aug 28, 2021·Biology·Rancés BlancoFrancisco Aguayo
Aug 31, 2021·Seminars in Radiation Oncology·Pippa F CosperRandall J Kimple