HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

Journal of the National Cancer Institute
Xavier CastellsaguéICO International HPV in Head and Neck Cancer Study Group

Abstract

We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation. Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV-DNA detection. Samples containing HPV-DNA were further subject to HPV E6*I mRNA detection and to p16(INK4a), pRb, p53, and Cyclin D1 immunohistochemistry. Final estimates of HPV-AFs were based on HPV-DNA, HPV E6*I mRNA, and/or p16(INK4a) results. A total of 3680 samples yielded valid results: 1374 pharyngeal, 1264 OC, and 1042 laryngeal cancers. HPV-AF estimates based on positivity for HPV-DNA, and for either HPV E6*I mRNA or p16(INK4a), were 22.4%, 4.4%, and 3.5% for cancers of the oropharynx, OC, and larynx, respectively, and 18.5%, 3.0%, and 1.5% when requiring simultaneous positivity for all three markers. HPV16 was largely the most common type. Estimates of HPV-AF in the oropharynx were highest in South America, Central and Eastern Europe, and Northern Eur...Continue Reading

References

Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Dec 5, 2003·Journal of the National Cancer Institute·Rolando HerreroUNKNOWN IARC Multicenter Oral Cancer Study Group
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aimee R KreimerSilvia Franceschi
Aug 8, 2007·International Journal of Cancer. Journal International Du Cancer·Serge J SmeetsRuud H Brakenhoff
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Anders NäsmanTina Dalianis
Apr 8, 2009·The Lancet Oncology·Véronique BouvardUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Oct 19, 2010·The Lancet Oncology·Silvia de SanjoseUNKNOWN Retrospective International Survey and HPV Time Trends Study Group
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Apr 20, 2012·International Journal of Cancer. Journal International Du Cancer·Gordana HalecMichael Pawlita
May 12, 2012·The Lancet Oncology·Catherine de MartelMartyn Plummer
Jun 20, 2012·The Journal of Pathology·Daan GeraetsUNKNOWN RIS HPV TT Study Group
Jul 13, 2012·Head and Neck Pathology·Max RobinsonSelvam Thavaraj
Mar 5, 2013·International Journal of Cancer. Journal International Du Cancer·Dana HolzingerFranz X Bosch
Nov 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
May 13, 2014·International Journal of Cancer. Journal International Du Cancer·Laia AlemanyUNKNOWN HPV VVAP Study Group
May 1, 2015·Journal of the National Cancer Institute·Mona SaraiyaUNKNOWN HPV Typing of Cancers Workgroup

❮ Previous
Next ❯

Citations

May 28, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suzanne M GarlandChristine Velicer
Aug 18, 2016·Oral Oncology·Sreenath Arekunnath MadathilBelinda Nicolau
Sep 11, 2016·Journal of Voice : Official Journal of the Voice Foundation·Massimo FusconiMarco de Vincentiis
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marta Félez-SánchezUNKNOWN VVAPO/RIS HPV TT study groups
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Elena-Sophie PriggeMiriam Reuschenbach
Dec 10, 2016·Journal of Medical Virology·Giulia CiccareseFrancesco Drago
Jan 22, 2017·International Journal of Cancer. Journal International Du Cancer·Devasena AnantharamanGypsyamber D'Souza
Mar 21, 2017·International Journal of Cancer. Journal International Du Cancer·Dana HolzingerTim Waterboer
Apr 4, 2017·International Journal of Cancer. Journal International Du Cancer·Tarik GheitUNKNOWN HPV-AHEAD study group
Apr 5, 2017·British Journal of Cancer·Núria GuimeràF Xavier Bosch
May 26, 2017·Journal of Oncology Practice·Silvia de SanjoséSilvina Arrossi
Jun 1, 2017·The Laryngoscope·Nicole D FacompreDevraj Basu
Apr 4, 2017·International Journal of Cancer. Journal International Du Cancer·Catherine de MartelSilvia Franceschi
Apr 26, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Evren ErkulDilaver Demirel
Jun 18, 2017·Microbes and Infection·Farhoud FarajiDaria A Gaykalova
Dec 3, 2016·Nature Reviews. Disease Primers·Mark SchiffmanSilvia Franceschi
Dec 22, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Diana BrauswetterIstvan Petak
Mar 3, 2018·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 14, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I H NautaC R Leemans
Dec 19, 2017·Archives of Pathology & Laboratory Medicine·James S LewisWilliam C Faquin
Oct 7, 2017·International Journal of Cancer. Journal International Du Cancer·Louise F WilsonDavid C Whiteman
Jun 1, 2018·Archives of Pathology & Laboratory Medicine·Barbara S Ducatman
Jun 8, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yungan TaoJean Bourhis
May 16, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·K K JensenC von Buchwald
Sep 5, 2018·European Journal of Oral Sciences·Stina Syrjänen
Sep 21, 2018·PloS One·Laurent AbramowitzStève Bénard
Sep 8, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·X J David LuCatherine F Poh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.