HPV prevalence and type distribution in Cypriot women with cervical cytological abnormalities

BMC Infectious Diseases
George KrashiasChristina Christodoulou

Abstract

Human papillomavirus (HPV) is the most common sexually transmitted agent, and it can cause cervical lesions and cancer in females. Currently, information regarding the prevalence of HPV in Cyprus is lacking. The aim of this study was to evaluate the HPV type-specific prevalence in 596 women, aged 19-65 years, with cytological abnormalities. Additionally, in a subset of 348 women for whom cytology results of the Pap test were available, the association between HPV infection and cervical disease was investigated. HPV detection and typing was carried out using PCR and restriction fragment length polymorphism analysis, respectively. Overall, the HPV prevalence was 72.8%, and it was shown to be age dependent, with a decreasing prevalence until the age of 45 years (p = 0.0018, χ2). Two hundred and fifty-eight women (59.4%) were infected with high-risk HPV, 151 (34.8%) with low-risk HPV, and 25 (5.8%) with HPV types of unknown risk. The most common high-risk HPV type was HPV16 (17.7%), followed by HPV31 (12.9%), HPV58 (7.1%), HPV68 (4.6%), HPV18 (4.1%), and HPV56 (3.7%). Among the women for whom cytology results were available, 268 (77%) were HPV positive, with a sample distribution as follows: 188 (74%) had atypical squamous cells of...Continue Reading

References

Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I LombardX Sastre-Garau
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Mar 29, 2002·Journal of Clinical Pathology·F X BoschK V Shah
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Oct 17, 2003·Clinics in Laboratory Medicine·Michael R Henry
Oct 24, 2003·Sexually Transmitted Infections·K A EthierJ R Ickovics
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Janet G Baseman, Laura A Koutsky
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary M CliffordJeanne M Pimenta
Jul 14, 2005·Scandinavian Journal of Infectious Diseases·Mario RassuGiorgio Palu'
Oct 16, 2007·Journal of Medical Virology·Efstathia PanotopoulouGeorge Magiakos
Jul 29, 2008·International Journal of Cancer. Journal International Du Cancer·Susanne K KjaerThomas Iftner
Oct 19, 2010·The Lancet Oncology·Silvia de SanjoseUNKNOWN Retrospective International Survey and HPV Time Trends Study Group
Nov 3, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A PistaF Ribeiro
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Dec 31, 2011·Enfermedades infecciosas y microbiología clínica·Diego DelgadoAndrés Canut
Feb 11, 2012·International Journal of Cancer. Journal International Du Cancer·Peng GuanGary M Clifford
Nov 8, 2012·Virology Journal·André L P AbreuMarcia E L Consolaro
Feb 1, 2013·BMC Infectious Diseases·Elena ArgyriEfstathia Panotopoulou
Mar 25, 2014·Gynecologic Oncology·Elizabeth L DicksonLevi S Downs
Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Marius Alexandru MogaVictoria Burtea
Sep 10, 2014·Journal of Medical Virology·Vaida SimanavicieneAurelija Zvirbliene
Dec 11, 2014·World Journal of Clinical Oncology·Ricardo Rosales, Carlos Rosales

❮ Previous
Next ❯

Citations

Jan 19, 2019·Current Drug Metabolism·Yuhua YaoBo Liao
Oct 13, 2018·International Journal of Environmental Research and Public Health·María Inmaculada Rodríguez-ÁlvarezGuillermo A Cañadas-De la Fuente

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
genotyping
amputation

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.